Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy
Ruxanda Moschoi(Inserm), Véronique Imbert(Inserm), Marielle Nebout(Inserm), Johanna Chiche(Inserm), D. A. S. G. Mary(Inserm), Thomas Prébet(Institut Paoli-Calmettes), Estelle Saland(Centre de Recherche en Cancérologie de Toulouse), Rémy Castellano(Centre National de la Recherche Scientifique), Laurent Pouyet(Centre National de la Recherche Scientifique), Yves Collette(Centre National de la Recherche Scientifique), Norbert Vey(Institut Paoli-Calmettes), Christian Chabannon(Institut Paoli-Calmettes), Christian Récher(Centre de Recherche en Cancérologie de Toulouse), Jean‐Emmanuel Sarry(Centre de Recherche en Cancérologie de Toulouse), Damien Alcor(Inserm), Jean‐François Peyron(Inserm), Emmanuel Griessinger(Inserm)
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Abstract
Key Points Bone marrow mesenchymal stromal cells transfer functional mitochondria to AML cells in vitro and in vivo through endocytic pathways. This mitochondria transfer is enhanced by some chemotherapies and confers a survival advantage to leukemic blasts and leukemia initiating cells.
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