Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Cristian Pattaro(Eurac Research), Alexander Teumer(Universitätsmedizin Greifswald), Mathias Gorski(University Hospital Regensburg), Audrey Y. Chu(Brigham and Women's Hospital), Man Li(Brigham and Women's Hospital), Vladan Mijatovic(University of Verona), Maija Garnaas(Brigham and Women's Hospital), Adrienne Tin(Johns Hopkins University), Rossella Sorice(Institute of Genetics and Biophysics), Yong Li(University of Freiburg), Daniel Taliun(Eurac Research), Matthias Olden(University Hospital Regensburg), Meredith C. Foster(Tufts University), Qiong Yang(Boston University), Ming‐Huei Chen(Boston University), Tune H. Pers(Broad Institute), Andrew D. Johnson(Framingham Heart Study), Yi-An Ko(University of Pennsylvania), Christian Fuchsberger(Eurac Research), Bamidele O. Tayo(Loyola University Medical Center), Michael A. Nalls(National Institute on Aging), Mary F. Feitosa(Washington University in St. Louis), Aaron Isaacs(Erasmus MC), Abbas Dehghan(Erasmus MC), Pio D’Adamo(University of Trieste), Adebowale Adeyemo(National Human Genome Research Institute), Aida Karina Dieffenbach(German Cancer Research Center), Alan B. Zonderman(National Institutes of Health), Ilja M. Nolte(University Medical Center Groningen), Peter J. van der Most(University Medical Center Groningen), Alan F. Wright(Institute of Genetics and Cancer), Alan R. Shuldiner(University of Maryland, Baltimore), Alanna C. Morrison(The University of Texas Health Science Center at Houston), Albert Hofman(Erasmus MC), Albert V. Smith(University of Iceland), Albert W. Dreisbach(State Street (United States)), André Franke(Christian-Albrechts-Universität zu Kiel), André G. Uitterlinden(Erasmus MC), Andres Metspalu(Estonian Biocentre), Anke Tönjes(Leipzig University of Applied Sciences), Antonio Lupo(University of Verona), Antonietta Robino(University of Trieste), Åsa Johansson(Uppsala University), Ayşe Demirkan(Erasmus MC), Barbara Kollerits(Innsbruck Medical University), Barry I. Freedman(Wake Forest University), Belén Ponte(University of Geneva), Ben A. Oostra(Erasmus MC), Bernhard Paulweber(Paracelsus Medical University), Bernhard K. Krämer(Heidelberg University), Braxton D. Mitchell(University of Maryland, Baltimore), Brendan M. Buckley(University College Cork), Carmen A. Peralta(San Francisco VA Medical Center), Caroline Hayward(Institute of Genetics and Cancer), Catherine Helmer(Inserm), Charles N. Rotimi(National Human Genome Research Institute), Christian M. Shaffer(Vanderbilt University), Christian Müller(Universität Hamburg), Cinzia Sala(Vita-Salute San Raffaele University), Cornelia M. van Duijn(Erasmus MC), Aude Saint-Pierre(Eurac Research), Daniel Ackermann(University of Geneva), Daniel Shriner(National Human Genome Research Institute), Daniela Ruggiero(Institute of Genetics and Biophysics), Daniela Toniolo(Vita-Salute San Raffaele University), Yingchang Lu(Child Health and Development Institute), Daniele Cusi(University of Milan), Darina Czamara(Max Planck Institute of Psychiatry), David Ellinghaus(Christian-Albrechts-Universität zu Kiel), David S. Siscovick(University of Washington), Douglas M. Ruderfer(Icahn School of Medicine at Mount Sinai), Christian Gieger(Helmholtz Zentrum München), Harald Grallert(Helmholtz Zentrum München), Elena Rochtchina(The University of Sydney), Elizabeth J. Atkinson(Mayo Clinic), Elizabeth G. Holliday(Hunter Medical Research Institute), Eric Boerwinkle(The University of Texas Health Science Center at Houston), Erika Salvi(University of Milan), Erwin P. Böttinger(Child Health and Development Institute), Federico Murgia(University of Sassari), Fernando Rivadeneira(Erasmus MC), Florian Ernst(Universität Greifswald), Florian Kronenberg(Innsbruck Medical University), Frank B. Hu(Harvard University), Gerjan Navis(University Medical Center Groningen), Gary C. Curhan(Brigham and Women's Hospital), G. Ehret(University Hospital of Geneva), Georg Homuth(Universität Greifswald), Stefan Coassin(Innsbruck Medical University), Gian Andri Thun(Swiss Tropical and Public Health Institute), Giorgio Pistis(Vita-Salute San Raffaele University), Giovanni Gambaro(Agostino Gemelli University Polyclinic), Giovanni Malerba(University of Verona), Grant W. Montgomery(QIMR Berghofer Medical Research Institute), Guðný Eiríksdóttir(Icelandic Heart Association), Gunnar Jacobs(Christian-Albrechts-Universität zu Kiel), Li Guo(University of Washington), H-Erich Wichmann(Zimmer Biomet (Netherlands)), Harry Campbell(Glasgow Centre for Population Health), Helena Schmidt(Medical University of Graz), Henri Wallaschofski(Universitätsmedizin Greifswald), Henry Völzke(Universitätsmedizin Greifswald), Hermann Brenner(German Cancer Research Center), Heyo K. Kroemer(Friedrich-Loeffler-Institut), Holly Kramer(Loyola University Medical Center), Honghuang Lin(Boston University), Irene Mateo Leach(University Medical Center Groningen), Ian Ford(The Robertson Trust), Idris Guessous(University of Geneva), Igor Rudan(Glasgow Centre for Population Health), Inga Prokopenko(Genomics (United Kingdom)), Ingrid B. Borecki(Washington University in St. Louis), Iris M. Heid(Helmholtz Zentrum München), Ivana Kolčić(University of Split), Ivana Persico(University of Sassari), J. Wouter Jukema(Netherlands Institute for Neuroscience), James F. Wilson(Glasgow Centre for Population Health), Janine F. Felix(Erasmus MC), Jasmin Divers(Wake Forest University), Jean‐Charles Lambert(Inserm), Jeanette M. Stafford(Wake Forest University), Jean-Michel Gaspoz(University of Geneva), Jennifer A. Smith(University of Michigan), Jessica D. Faul(University of Michigan), Jie Jin Wang(The University of Sydney), Jingzhong Ding(Wake Forest University), Joel N. Hirschhorn(Broad Institute), John Attia(Mayo Clinic), John B. Whitfield(QIMR Berghofer Medical Research Institute), John Chalmers(The University of Sydney), Jorma Viikari(University of Turku), Josef Coresh(Johns Hopkins University), Joshua C. Denny(Vanderbilt University), Juha Karjalainen(University Medical Center Groningen), Jyotika K. Fernandes(Medical University of South Carolina), Karlhans Endlich(Friedrich-Loeffler-Institut), Katja Butterbach(German Cancer Research Center), Keith L. Keene(East Carolina University), Kurt Lohman(Wake Forest University), Laura Portas(University of Sassari), Lenore J. Launer(Institute on Aging), Leo‐Pekka Lyytikäinen(Tampere University), Loïc Yengo(Centre National de la Recherche Scientifique), Lude Franke(University Medical Center Groningen), Luigi Ferrucci(National Institute on Aging), Lynda M. Rose(Brigham and Women's Hospital), Lyudmyla Kedenko(Paracelsus Medical University), Madhumathi Rao(Tufts University), Maksim Struchalin(Erasmus MC), Marcus E. Kleber(Heidelberg University), Margherita Cavalieri(Medical University of Graz), Margot Haun(Innsbruck Medical University), Marilyn C. Cornelis(Harvard University), Marina Ciullo(Institute of Genetics and Biophysics), Mario Pirastu(University of Sassari), Mariza de Andrade(Mayo Clinic), Mark McEvoy(John Hunter Hospital), Mark Woodward(The University of Sydney), Martin Adam(Swiss Tropical and Public Health Institute), Massimiliano Cocca(Vita-Salute San Raffaele University), Matthias Nauck(Universitätsmedizin Greifswald), Medea Imboden(Swiss Tropical and Public Health Institute), Mélanie Waldenberger(Helmholtz Zentrum München), Menno Pruijm(University of Lausanne), Marie Metzger(Université Paris-Sud), Michael Stümvoll(Leipzig University of Applied Sciences), Michele K. Evans(National Institutes of Health), Michèle M. Sale(University of Virginia), Mika Kähönen(Tampere University Hospital), Mladen Boban(University of Split), Murielle Bochud(University Hospital of Lausanne), Myriam Rheinberger(University Hospital Regensburg), Niek Verweij(University Medical Center Groningen), Nabila Bouatia‐Naji(Délégation Paris 5), Nicholas G. Martin(Brigham and Women's Hospital), Nick Hastie(Institute of Genetics and Cancer), Nicole Probst‐Hensch(Swiss Tropical and Public Health Institute), Nicole Soranzo(Wellcome Sanger Institute), Olivier Devuyst(ZHAW Zurich University of Applied Sciences), Olli T. Raitakari(University of Turku), Omri Gottesman(Child Health and Development Institute), Oscar H. Franco(Erasmus MC), Ozren Polašek(University of Split), Paolo Gasparini(University of Trieste), Patricia B. Munroe(Queen Mary University of London), Paul M. Ridker(Harvard University), Paul Mitchell(The University of Sydney), Paul Muntner(University of Alabama at Birmingham), Christa Meisinger(Helmholtz Zentrum München), Johannes H. Smit(Amsterdam Public Health), Gonçalo R. Abecasis(University of Michigan), Linda S. Adair(University of North Carolina at Chapel Hill), M Alexander(University of Cambridge), David Altshuler(Harvard University), Najaf Amin(Erasmus MC), Dan E. Arking(Johns Hopkins University), Pankaj Arora(Massachusetts General Hospital), Yurii S. Aulchenko(Erasmus MC), Stephan J. L. Bakker(University Medical Center Groningen), Stefania Bandinelli(Azienda Sanitaria di Firenze), Inês Barroso(Wellcome Sanger Institute), J. Beckmann(University of Lausanne), John Beilby(The University of Western Australia), Richard N. Bergman(University of Southern California), Sven Bergmann(University of Lausanne), Joshua C. Bis(University of Washington), Michael Boehnke(University of Michigan), Lori L. Bonnycastle(National Institutes of Health), Stefan R. Bornstein(University Hospital Carl Gustav Carus), Michiel L. Bots(Heidelberg University), Jennifer L. Bragg‐Gresham(University of Michigan), Stefan-Martin Brand(University of Münster), Eva Brand(University Hospital Münster), Peter S. Braund(University of Leicester), Morris J. Brown(University of Cambridge), Paul R. Burton(University of Leicester), Juan P. Casas(University of London), Mark J. Caulfield(Queen Mary University of London), Aravinda Chakravarti(Johns Hopkins University), John C. Chambers(Imperial College London), Giriraj R. Chandak(Centre for Cellular and Molecular Biology), Yen-Pei C. Chang(University of Maryland, Baltimore), Fadi J. Charchar(Federation University), Nish Chaturvedi(Imperial College London), Yoon Shin Cho(Korea National Institute of Health), Robert Clarke(University of Oxford), Francis S. Collins(National Institutes of Health), Rory Collins(University of Oxford), John Connell(University of Dundee), Jackie A. Cooper(University College London), Matthew N. Cooper(The University of Western Australia), Richard S. Cooper, A. Corsi(Agenzia Regionale di Sanità della Toscana), Marcus Dörr(Universität Greifswald), Santosh Dahgam(University of Gothenburg), John Danesh(University of Cambridge), George Davey Smith(University of Bristol), Ian N.M. Day(University of Bristol), Panos Deloukas(Wellcome Sanger Institute), Matthew Denniff(University of Leicester), Anna F. Dominiczak(University of Glasgow), Yanbin Dong(Prevention Institute), Ayo P. Doumatey(National Human Genome Research Institute), Paul Elliott(Imperial College London), Roberto Elosúa(Barcelona Biomedical Research Park), Jeanette Erdmann(University of Lübeck), S. Eyheramendy(Pontificia Universidad Católica de Chile), Martin Farrall(Centre for Human Genetics), Cristiano Fava(Lund University), Terrence Forrester(University of the West Indies System), F.G.R. Fowkes(University of Edinburgh), Ervin R. Fox(Jackson Memorial Hospital), Timothy M. Frayling(University of Exeter), Pilar Galán(Inserm), Santhi K. Ganesh(University of Michigan), Melissa García(National Institutes of Health), Tom R. Gaunt(University of Bristol), Nicole L. Glazer(University of Washington), Min Jin Go(Korea National Institute of Health), Anuj Goel(Centre for Human Genetics), Jürgen Gräßler(University Hospital Carl Gustav Carus), Diederick E. Grobbee(Heidelberg University), Leif Groop, Simonetta Guarrera(Italian institute for Genomic Medicine), Xiuqing Guo(Cedars-Sinai Medical Center), David Hadley(St George's, University of London), Anders Hamsten(Karolinska Institutet), Bok-Ghee Han(Korea National Institute of Health), Rebecca Hardy(MRC Unit for Lifelong Health and Ageing), Anna-Liisa Hartikainen(University of Oulu), Simon Heath(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Susan R. Heckbert(University of Washington), Bo Hedblad(Lund University), Serge Herçberg(Inserm), Dena Hernández(National Institute on Aging), Andrew A. Hicks(Eurac Research), Gina M. Hilton(Johns Hopkins University), Aroon D. Hingorani(Public Health England), Judith A. Hoffman Bolton(Johns Hopkins University), Jemma C. Hopewell(University of Oxford), Philip Howard(Queen Mary University of London), Steve E. Humphries(University College London), Steven C. Hunt(University of Utah), Kristian Hveem(Norwegian University of Science and Technology), M. Arfan Ikram(Erasmus MC), Saiful Islam(Aga Khan University), Naoharu Iwai(National Cerebral and Cardiovascular Center), Marjo‐Riitta Järvelin(Imperial College London), Anne Jackson(University of Michigan), Tazeen H. Jafar(Aga Khan University), Charles S. Janipalli(Centre for Cellular and Molecular Biology), Toby Johnson(Queen Mary University of London), Sekar Kathiresan(Broad Institute), Kay‐Tee Khaw(University of Cambridge), Hyung‐Lae Kim(Korea National Institute of Health), Sanjay Kinra(University of London), Yoshikuni Kita(Shiga University of Medical Science), Mika Kivimäki(Public Health England), Jaspal S. Kooner(Imperial College London), G Anil Kumar(Centre for Cellular and Molecular Biology), Diana Kuh(MRC Unit for Lifelong Health and Ageing), Smita Kulkarni(Dr. D. Y. Patil Medical College, Hospital and Research Centre), Meena Kumari(MRC Epidemiology Unit), Johanna Kuusisto(Kuopio University Hospital), Tatiana Kuznetsova(KU Leuven), Markku Laakso(Kuopio University Hospital), Maris Laan(University of Tartu), Jaana Laitinen(Finnish Institute of Occupational Health), Edward G. Lakatta(National Institute on Aging), Carl D. Langefeld(Wake Forest University), Martin G. Larson(National Heart Lung and Blood Institute), Mark Lathrop(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Debbie A. Lawlor(University of Bristol), Robert Lawrence(The University of Western Australia), Jong‐Young Lee(Korea National Institute of Health), Sang Lee(Foundation University), Daniel Levy(National Heart Lung and Blood Institute), Yali Li(University of Freiburg), W. T. Longstreth(University of Washington), Jian’an Luan(MRC Epidemiology Unit), Gavin Lucas(Barcelona Biomedical Research Park), Barbara Ludwig(University Hospital Carl Gustav Carus), Massimo Mangino(King's College London), K. Radha Mani(Centre for Cellular and Molecular Biology), Michael Marmot(Public Health England), Francesco Mattace‐Raso(Erasmus MC), Giuseppe Matullo(University of Turin), Wendy L. McArdle(University of Bristol), Colin A. McKenzie(University of the West Indies System), Thomas Meitinger(Helmholtz Zentrum München), Olle Melander(Lund University), Pierre Meneton(Inserm), James F. Meschia(WinnMed), Tetsuro Miki(Ehime University), Yuri Milaneschi(National Institute on Aging), Karen L. Mohlke(University of North Carolina at Chapel Hill), Vincent Mooser(GlaxoSmithKline (United States)), Mario A. Morken(National Institutes of Health), Richard Morris(University College London), Thomas H. Mosley(University of Mississippi Medical Center), Samer S. Najjar(National Institute on Aging), Narisu Narisu(National Institutes of Health), Christopher Newton‐Cheh(Massachusetts General Hospital), Khanh-Dung H. Nguyen(Johns Hopkins University), Peter M. Nilsson(Lund University), Fredrik Nyberg(University of Gothenburg), Christopher J. O’Donnell(National Heart Lung and Blood Institute), Toshio Ogihara(The University of Osaka), Takayoshi Ohkubo(Tohoku University), Tomonori Okamura(National Cerebral and Cardiovascular Center), RickTwee-Hee Ong(Agency for Science, Technology and Research), Halit Ongen(Centre for Human Genetics), N. Charlotte Onland‐Moret(Heidelberg University), Paul F. O’Reilly(Imperial College London), Elin Org(University of Tartu), Marco Orrù(Institute of Genetic and Biomedical Research), Walter Palmas(Columbia University), Jutta Palmen(University College London), Lyle J. Palmer(The University of Western Australia), Nicholette D. Palmer(Wake Forest University), Alex Parker(Amgen (United States)), John F. Peden(Centre for Human Genetics), Leena Peltonen(Wellcome Sanger Institute), Markus Perola(Finnish Institute for Health and Welfare), Vasyl Pihur(Johns Hopkins University), Carl G. P. Platou(Norwegian University of Science and Technology), Andrew Plump(Merck & Co., Inc., Rahway, NJ, USA (United States)), Dorairaj Prabhakaran(Public Health Foundation of India), Bruce M. Psaty(University of Washington), Leslie J. Raffel(Cedars-Sinai Medical Center), D. C. Rao(Washington University in St. Louis), Asif Rasheed(Center for Non-Communicable Diseases), Fulvio Ricceri(University of Turin), Kenneth Rice(University of Washington), Annika Rosengren(University of Gothenburg), Jerome I. Rotter(Cedars-Sinai Medical Center), Megan E. Rudock(Wake Forest University), Siim Sõber(University of Tartu), Tunde Salako(University of Ibadan), Danish Saleheen(Center for Non-Communicable Diseases), Veikko Salomaa(Finnish Institute for Health and Welfare), Nilesh J. Samani(University of Leicester), Steven M. Schwartz(University of Washington), Peter Schwarz(University Hospital Carl Gustav Carus), Laura J. Scott(University of Michigan), James Scott(Imperial College London), Angelo Scuteri(National Institute on Aging), Joban Sehmi(Imperial College London), Mark Seielstad(University of California, San Francisco), Sudha Seshadri(Boston University), Pankaj Sharma(Imperial College London), Sue Shaw‐Hawkins(Queen Mary University of London), Gang Shi(Washington University in St. Louis), Nick Shrine(University of Leicester), Eric J.G. Sijbrands(Erasmus MC), Xueling Sim(National University of Singapore), Andrew B. Singleton(National Institute on Aging), Marketa Sjögren(Lund University), Nicholas L. Smith(University of Washington), María Soler Artigas(University of Leicester), Tim D. Spector(King's College London), Jan A. Staessen(Finnish Institute of Occupational Health), Alena Stančáková(Kuopio University Hospital), Nanette Steinle(University of Maryland, Baltimore), David P. Strachan(St George's, University of London), Heather M. Stringham(University of Michigan), Yan V. Sun(University of Michigan), Amy J. Swift(National Institutes of Health), Yasuharu Tabara(Ehime University), E Shyong Tai(National University of Singapore), Philippa J. Talmud(University College London), Andrew M. Taylor(MRC Epidemiology Unit), Janoš Terzić(University of Split), Dag S. Thelle(University of Oslo), Martin D. Tobin(Queen Mary University of London), Maciej Tomaszewski(University of Leicester), Vikal Tripathy(Public Health Foundation of India), Jaakko Tuomilehto(Finnish Institute for Health and Welfare), Ioanna Tzoulaki(Imperial College London), Manuela Uda(Institute of Genetic and Biomedical Research), Hirotsugu Ueshima(Shiga University of Medical Science), Cuno S.P.M. Uiterwaal(University Hospital Münster), Satoshi Umemura(Yokohama City University), Pim van der Harst(University Medical Center Groningen), Yvonne T. van der Schouw(Heidelberg University), Wiek H. van Gilst(University Medical Center Groningen), Erkki Vartiainen(Finnish Institute for Health and Welfare), Ramachandran S. Vasan(National Heart Lung and Blood Institute), Gudrun Veldre(University of Tartu), Germaine C. Verwoert(Erasmus MC), Margus Viigimaa(Tallinn University of Technology), D. G. Vinay(Centre for Cellular and Molecular Biology), Paolo Vineis(Imperial College London), Benjamin F. Voight(Broad Institute), Péter Vollenweider(University Hospital of Lausanne), Lynne E. Wagenknecht(Wake Forest University), Louise V. Wain(University of Leicester), Xiaoling Wang(Prevention Institute), Thomas J. Wang(National Heart Lung and Blood Institute), Nicholas J. Wareham(MRC Epidemiology Unit), Hugh Watkins(Centre for Human Genetics), Alan B. Weder(University of Michigan), Peter H. Whincup(St George's, University of London), Kerri L. Wiggins(University of Washington), Jacqueline C.M. Witteman(Erasmus MC), Andrew Wong(MRC Unit for Lifelong Health and Ageing), Ying Wu(Ehime University), Chittaranjan S. Yajnik(Dr. D. Y. Patil Medical College, Hospital and Research Centre), Jie Yao(Cedars-Sinai Medical Center), J. Hunter Young(Johns Hopkins University), Diana Zélénika(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Guangju Zhai(King's College London), Weihua Zhang(Imperial College London), Feng Zhang(King's College London), Wei Zhao(MRC Epidemiology Unit), Haidong Zhu(Prevention Institute), Xiaofeng Zhu(Cornell University), Paavo Zitting(Lapland Central Hospital), E Zukowska-Szczechowska(Medical University of Silesia), Yukinori Okada(RIKEN Center for Integrative Medical Sciences), Jer-Yuarn Wu(Institute of Biomedical Sciences, Academia Sinica), Dongfeng Gu(Chinese Academy of Medical Sciences & Peking Union Medical College), Fumihiko Takeuchi(National Center for Global Health and Medicine), Atsushi Takahashi(RIKEN Center for Integrative Medical Sciences), Shiro Maeda(RIKEN Center for Integrative Medical Sciences), Tatsuhiko Tsunoda(RIKEN Center for Integrative Medical Sciences), Peng Chen(National University of Singapore), Su-Chi Lim(Khoo Teck Puat Hospital), Tien Yin Wong(Singapore National Eye Center), Jianjun Liu(Agency for Science, Technology and Research), Terri L. Young(Center for Human Genetics), Tin Aung(Singapore National Eye Center), Yik-Ying Teo(Agency for Science, Technology and Research), Young Jin Kim(Korea National Institute of Health), Daehee Kang(Seoul National University), Chien‐Hsiun Chen(Institute of Biomedical Sciences, Academia Sinica), Fuu‐Jen Tsai(China Medical University), Li-Ching Chang(Institute of Biomedical Sciences, Academia Sinica), SJ Fann(Institute of Biomedical Sciences, Academia Sinica), Hao Mei(Tulane University), James E. Hixson(The University of Texas Health Science Center at Houston), Shufeng Chen(Chinese Academy of Medical Sciences & Peking Union Medical College), Tomohiro Katsuya(The University of Osaka), Masato Isono(National Center for Global Health and Medicine), Eva Albrecht(Helmholtz Zentrum München), Kazuhiko Yamamoto(The University of Tokyo), Michiaki Kubo(RIKEN Center for Integrative Medical Sciences), Yusuke Nakamura(Tokyo University of Science), Naoyuki Kamatani(RIKEN Center for Integrative Medical Sciences), Norihiro Kato(National Center for Global Health and Medicine), Jiang He(Tulane University), Yuan-Tsong Chen(Institute of Biomedical Sciences, Academia Sinica), Toshihiro Tanaka(Tokyo Medical and Dental University), CARDIOGRAM(Cardiovascular Institute of the South), Muredach P. Reilly(Institute for Integrative and Experimental Genomics), Heribert Schunkert(Stanford University), Themistocles L. Assimes(University of Leeds), Alistair S. Hall(University Hospital Regensburg), Christian Hengstenberg(University of Lübeck), Inke R. König(Tampere University Hospital), Reijo Laaksonen(University of Ottawa), Ruth McPherson(University of Leicester), John R. Thompson(deCODE Genetics (Iceland)), Unnur Þorsteinsdóttir(University of Lübeck), Andreas Ziegler(HudsonAlpha Institute for Biotechnology), Devin Absher(University of Ottawa), Li Chen(National Heart Lung and Blood Institute), L. Adrienne Cupples(Tel Aviv University), Eran Halperin(University of Pennsylvania), Mingyao Li(Johns Hopkins University), Kiran Musunuru(Institute for Integrative and Experimental Genomics), Michael Preuß(University of Lübeck), Arne Schillert(deCODE Genetics (Iceland)), Guðmar Þorleifsson(University of Ottawa), George A. Wells(deCODE Genetics (Iceland)), Hilma Hólm(University of Ottawa), Robert Roberts(University of Ottawa), Alexandre F.R. Stewart(Stanford University), Stephen P. Fortmann(Kaiser Permanente), Alan S. Go(Stanford University), Mark A. Hlatky(Kaiser Permanente), Carlos Iribarren(Stanford University), Joshua W. Knowles(HudsonAlpha Institute for Biotechnology), Richard H. Myers(Stanford University), Thomas Quertermous(Kaiser Permanente), Steven Sidney(University of California, San Francisco), Neil Risch(Cleveland Clinic), Hua Tang(Johannes Gutenberg University Mainz), Stefan Blankenberg(Johannes Gutenberg University Mainz), Renate B. Schnabel(Johannes Gutenberg University Mainz), Christoph Sinning(Johannes Gutenberg University Mainz), Karl J. Lackner(Inserm), Laurence Tiret(Inserm), Viviane Nicaud(Inserm), François Cambien(Johannes Gutenberg University Mainz), Christoph Bickel(Johannes Gutenberg University Mainz), Hans J. Rupprecht(Inserm), Claire Perret(Inserm), Carole Proust(Johannes Gutenberg University Mainz), Thomas F. Münzel(The University of Texas Health Science Center at Houston), Maja Barbalić(Cedars-Sinai Medical Center), Ida Yii-Der Chen(Wake Forest University), Serkalem Demissie-Banjaw(University of Minnesota), Aaron R. Folsom(Center for Non-Communicable Diseases), Thomas Lumley(University of Washington), Kristin D. Marciante(Cedars-Sinai Medical Center), Kent D. Taylor(The University of Texas Health Science Center at Houston), Kelly A. Volcik(deCODE Genetics (Iceland)), Sólveig Grétarsdóttir(deCODE Genetics (Iceland)), Jeffrey R. Gulcher(deCODE Genetics (Iceland)), Augustine Kong(deCODE Genetics (Iceland)), Kāri Stefánsson(University of Iceland), Guðmundur Þorgeirsson(University of Iceland), Karl Andersen(University Hospital Regensburg), Marcus Fischer(Institute for Integrative and Experimental Genomics), Anika Großhennig(Institute for Integrative and Experimental Genomics), Patrick Linsel‐Nitschke(University Hospital Regensburg), Klaus Stark(Christian-Albrechts-Universität zu Kiel), Stefan Schreiber(Institute for Integrative and Experimental Genomics), Zouhair Aherrahrou(Institute for Integrative and Experimental Genomics), Petra Bruse(Helmholtz Zentrum München), Angela Doering(Helmholtz Zentrum München), Norman Klopp(Institute for Integrative and Experimental Genomics), Patrick Diemert(Institute for Integrative and Experimental Genomics), Christina Loley(Institute for Integrative and Experimental Genomics), Anja Medack(Institute for Integrative and Experimental Genomics), Janja Nahrstedt(Helmholtz Zentrum München), Annette Peters(Institute for Integrative and Experimental Genomics), Arnika Kathleen Wagner(Institute for Integrative and Experimental Genomics), Christina Willenborg(Universität Ulm), Bernhard Böhm(Medical University of Graz), Harald Dobnig(Synlab (Germany)), Tanja B. Grammer(University of Freiburg), Michael M. Hoffmann, Andreas Meinitzer(Kardiologie Frankfurt-Sachsenhausen), Bernhard R. Winkelmann(Medical University of Graz), Stefan Pilz, Wilfried Renner, Hubert Scharnagl, Tatjana Stojaković(Medical University of Graz), Andreas Tomaschitz(University of Freiburg), Karl Winkler(Broad Institute), Candace Guiducci(Broad Institute), Noël P. Burtt(Broad Institute), Stacey Gabriel(University of Ottawa), Sonny Dandona(University of Ottawa), Olga Jarinova(University of Pennsylvania), Liming Qu(Cardiovascular Institute of the South), Robert Wilensky(Cardiovascular Institute of the South), William Matthai(Children's Hospital of Philadelphia), Håkon Håkonarson(MedStar Washington Hospital Center), Joe Devaney(MedStar Washington Hospital Center), Mary Susan Burnett(MedStar Washington Hospital Center), Augusto D. Pichard(MedStar Washington Hospital Center), Kenneth M. Kent(MedStar Washington Hospital Center), Lowell Satler(MedStar Washington Hospital Center), Joseph Lindsay(MedStar Washington Hospital Center), Ron Waksman(GlaxoSmithKline (United States)), Christopher W. Knouff(GlaxoSmithKline (United States)), Dawn Waterworth(GlaxoSmithKline (United States)), Max Walker(MedStar Washington Hospital Center), Stephen E. Epstein(Cardiovascular Institute of the South), Daniel J. Rader(University of Leicester), Christopher P. Nelson(University of Leicester), Benjamin J. Wright(University of Leeds), Anthony J. Balmforth(University of Leeds), Stephen G. Ball(University of North Carolina at Chapel Hill), CHARGe-Heart Failure Group(University of North Carolina at Chapel Hill), Laura R. Loehr(National Heart Lung and Blood Institute), Wayne D. Rosamond(Cedars-Sinai Medical Center), Emelia J. Benjamin(University of North Carolina at Chapel Hill), Talin Haritunians(National Heart Lung and Blood Institute), David Couper(Boston University), Joanne M. Murabito(Erasmus MC), Ying A. Wang(University of North Carolina at Chapel Hill), Bruno H. Stricker(The University of Texas Health Science Center at Houston), Patricia P. Chang(Universität Greifswald), James T. Willerson(Medical University of Graz), Stephan B. Felix(National Heart Lung and Blood Institute), Norbert Watzinger(Medical University of Graz), Jayashri Aragam(Uppsala University), Robert Zweiker(Mayo Clinic), Lars Lind(Martin Luther University Halle-Wittenberg), Richard J. Rodeheffer(Erasmus MC), Karin Halina Greiser(University of Lübeck), Jaap W. Deckers(Karolinska Institutet), Jan Stritzke(Mayo Clinic), Erik Ingelsson(Martin Luther University Halle-Wittenberg), Iftikhar J. Kullo(Universität Greifswald), Johannes Haerting(Mayo Clinic), Thorsten Reffelmann(Martin Luther University Halle-Wittenberg), Margaret M. Redfield(National Heart Lung and Blood Institute), Karl Werdan(University of Alabama at Birmingham), Gary F. Mitchell(University of Maryland, Baltimore), Donna K. Arnett(Johannes Gutenberg University Mainz), John S. Gottdiener(Universität Greifswald), Maria Blettner(IFB Adiposity Diseases), Nele Friedrich(Johannes Gutenberg University Mainz), Péter Kovács(Université de Lille), Philipp S. Wild(Johannes Gutenberg University Mainz), Philippe Froguel(Centre National de la Recherche Scientifique), Rainer Rettig(Universitätsmedizin Greifswald), Reedik Mägi(Estonian Biocentre), Reiner Biffar(QIMR Berghofer Medical Research Institute), Reinhold Schmidt(Vanderbilt University), Rita P. S. Middelberg(QIMR Berghofer Medical Research Institute), Robert J. Carroll(Vanderbilt University), Brenda W.J.H. Penninx(University of Washington), Rodney J. Scott(John Hunter Hospital), Ronit Katz(University of Washington), Sanaz Sedaghat(University of Michigan), Sarah H. Wild(IRCCS Materno Infantile Burlo Garofolo), Sharon L. R. Kardia(University of Michigan), Sheila Ulivi(Uppsala University), Shih-Jen Hwang(Framingham Heart Study), Stefan Enroth(Uppsala University), Stefan Kloiber(Université Paris-Sud), Stella Trompet(Leiden University Medical Center), Bénédicte Stengel(Université Paris-Sud), Stephen Hancock(Hunter Medical Research Institute), Stephen T. Turner(Mayo Clinic), Sylvia E. Rosas(National Institute on Aging), Sylvia Stracke(Inserm), Tamara B. Harris(Institute on Aging), Tanja Zeller(Universität Hamburg), Tatijana Zemunik(Helmholtz Zentrum München), Terho Lehtimäki(University of Iceland), Thomas Illig(Helmholtz Zentrum München), Thor Aspelund(University of Iceland), Tiit Nikopensius(National Institute on Aging), Tõnu Esko(Uppsala University), Toshiko Tanaka(German Centre for Cardiovascular Research), Ulf Gyllensten(Uppsala University), Uwe Völker(Universitätsmedizin Greifswald), Valur Emilsson(University of Turku), Véronique Vitart(University of Iceland), Ville Aalto(Inserm), Vilmundur Guðnason(University of Iceland), Vincent Chouraki(Uppsala University), Wei‐Min Chen(Synlab (Germany)), Wilmar Igl(Uppsala University), Winfried März(Synlab Czech (Czechia)), Wolfgang Köenig(Universität Ulm), Wolfgang Lieb(Christian-Albrechts-Universität zu Kiel), Ruth J. F. Loos(University Medical Center Groningen), Ching‐Ti Liu(Wake Forest University), Harold Snieder(University of Maryland, Baltimore), Peter P. Pramstaller(University of Maryland, Baltimore), Afshin Parsa(University of Maryland, Baltimore), Jeffrey R. O’Connell(Université de Montréal), Katalin Suszták(Université de Montréal), Pavel Hamet(University of Washington), Johanne Tremblay(University Hospital Regensburg), Ian H. de Boer(Brigham and Women's Hospital), Carsten A. Böger(Harvard University), Wolfram Goessling(Brigham and Women's Hospital), Daniel I. Chasman(Brigham and Women's Hospital), Anna Köttgen(Brigham and Women's Hospital), W.H. Linda Kao(Johns Hopkins University), Caroline S. Fox(Brigham and Women's Hospital)
Cited by 535Open Access
Abstract
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
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