Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

Jian Zheng; Xudong Huang; Wen Tan; Dianke Yu; Zhongli Du; Jiang Chang; Lixuan Wei; Yaling Han; Chengfeng Wang; Xu Che; Yifeng Zhou; Xiaoping Miao; Guoliang Jiang; Xianjun Yu; Xianghong Yang; Guangwen Cao; Chaohui Zuo; Zhaoshen Li; Chunyou Wang; ST Cheung; Yongfeng Jia; Xiongwei Zheng; Hongbing Shen; Chen Wu; Dongxin Lin

doi:10.1038/ng.3568

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

Jian Zheng(Chinese Academy of Medical Sciences & Peking Union Medical College), Xudong Huang(Chinese Academy of Medical Sciences & Peking Union Medical College), Wen Tan(Chinese Academy of Medical Sciences & Peking Union Medical College), Dianke Yu(Chinese Academy of Medical Sciences & Peking Union Medical College), Zhongli Du(Chinese Academy of Medical Sciences & Peking Union Medical College), Jiang Chang(Chinese Academy of Medical Sciences & Peking Union Medical College), Lixuan Wei(Chinese Academy of Medical Sciences & Peking Union Medical College), Yaling Han(Chinese Academy of Medical Sciences & Peking Union Medical College), Chengfeng Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Xu Che(Chinese Academy of Medical Sciences & Peking Union Medical College), Yifeng Zhou(Soochow University), Xiaoping Miao(Huazhong University of Science and Technology), Guoliang Jiang(Fudan University Shanghai Cancer Center), Xianjun Yu(Fudan University Shanghai Cancer Center), Xianghong Yang(China Medical University), Guangwen Cao(Second Military Medical University), Chaohui Zuo(Hunan Cancer Hospital), Zhaoshen Li(Second Military Medical University), Chunyou Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), ST Cheung(University of Hong Kong), Yongfeng Jia(Inner Mongolia Medical University), Xiongwei Zheng(Fujian Provincial Cancer Hospital), Hongbing Shen(Nanjing Medical University), Chen Wu(Chinese Academy of Medical Sciences & Peking Union Medical College), Dongxin Lin(Sun Yat-sen University)

Nature Genetics

May 23, 2016

10.1038/ng.3568

Cited by 271

Abstract

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