Expression of α-smooth muscle actin in human's thoracic aorta dissection.

Abstract

Objective:To explore the relationship of α-smooth muscle actin(α-SMA) in human's thoracic aorta dissection(TAD).Methods:Tissue samples of dissected thoracic aorta(DA) and normal thoracic aorta(NA) were evaluated.Western Blotting and immunohistochemical studies were performed to detected α-SMA expression in tissues.Results:α-SMA expression was apparently downregulated in DA group,while proliferated phenotype was predominated among vascular smooth muscle cells.Conclusion:Expression of α-SMA was mainly downregulated in VSMC of vascular media wall.Phenotype change of VSMC was occurred sent so that elasticity of the media was lack and dissection of vascular was performed.Therefore,α-SMA might play a key role in the development of human's thoracic aorta dissection,which is need to be further explored.