The Human Vaccines Project: A roadmap for cancer vaccine development
Pedro Romero(Ludwig Cancer Research), Jacques Banchereau(Jackson Laboratory), Nina Bhardwaj(Icahn School of Medicine at Mount Sinai), Mark I. Cockett(Bristol-Myers Squibb (United States)), Mary L. Disis(University of Washington), Glenn Dranoff(Novartis (United States)), Eli Gilboa(Sylvester Comprehensive Cancer Center), Scott A. Hammond, Robert D. Hershberg(Bristol-Myers Squibb (Switzerland)), Alan J. Korman(Bristol-Myers Squibb (United States)), Pia Kvistborg(The Netherlands Cancer Institute), Cornelis J.M. Melief(Leiden University Medical Center), Ira Mellman, Karolina Palucka(Baylor University), Irina Redchenko(University of Oxford), Harlan Robins(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa), Federica Sallusto(Università della Svizzera italiana), Theodore Schenkelberg(World Resources Institute), Stephen P. Schoenberger(La Jolla Institute for Immunology), Jeffrey A. Sosman(Vanderbilt University Medical Center), Özlem Türeci(Centre for Individualised Infection Medicine), Benoı̂t Van den Eynde(Ludwig Cancer Research), Wayne C. Koff(International AIDS Vaccine Initiative), George Coukos(Ludwig Cancer Research)
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Abstract
Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited by most vaccines tested, but their clinical efficacy remains modest. We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.
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