Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona
Krishnendu Saha(University of Massachusetts Amherst), Mehran Rahimi(RWTH Aachen University), Mahdieh Yazdani(University of Massachusetts Amherst), Sung Tae Kim(University of Massachusetts Amherst), Daniel F. Moyano(University of Massachusetts Amherst), Singyuk Hou(University of Massachusetts Amherst), Ridhha Das(University of Massachusetts Amherst), Rubul Mout(University of Massachusetts Amherst), Farhad Rezaee(University Medical Center Groningen), Morteza Mahmoudi(Harvard University), Vincent M. Rotello(University of Massachusetts Amherst)
Cited by 340Open Access
Abstract
Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages.
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