Pd-Catalyzed C–H Lactonization for Expedient Synthesis of Biaryl Lactones and Total Synthesis of Cannabinol
Yan Li(University of Science and Technology of China), Yanjun Ding(University of Science and Technology of China), Jian‐Yong Wang(University of Science and Technology of China), Yiming Su(University of Science and Technology of China), Xi‐Sheng Wang(University of Science and Technology of China)
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Abstract
A practical Pd(II)/Pd(IV)-catalyzed carboxyl-directed C-H activation/C-O cyclization to construct biaryl lactones has been developed. The synthetic utility of this new reaction was demonstrated in an atom-economical and operationally convenient total synthesis of the natural product cannabinol from commercially available starting materials, with the newly developed method used for two key steps.
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