Rhenium-Catalyzed Regiodivergent Addition of Indoles to Terminal Alkynes

Dexin Xia(Chinese Academy of Sciences), Yin Wang(Northwest A&F University), Zhen‐Ting Du(Northwest A&F University), Qi‐Yu Zheng(Chinese Academy of Sciences), Congyang Wang(Northwest A&F University)
Organic Letters
December 29, 2011
Cited by 92

Abstract

An efficient rhenium-catalyzed site-switchable addition of indoles to terminal alkynes is described. A variety of bisindolylalkane derivatives are expeditiously synthesized in high yields with excellent regioselectivity. Preliminary mechanistic study sheds light on the observed regiodivergent addition.


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