Amplification and overexpression of the egf receptor gene in primary human glioblastomas
Towia A. Libermann(Weizmann Institute of Science), Harris R. Nusbaum(Weizmann Institute of Science), Nissim Razon(Tel Aviv Sourasky Medical Center), Richard Kris(Weizmann Institute of Science), Irit Lax(Weizmann Institute of Science), Hermona Soreq(Weizmann Institute of Science), Nigel Whittle(The Honourable Society of Lincoln's Inn), Michael D. Waterfield(The Honourable Society of Lincoln's Inn), Axel Ullrich(American Academy of Ophthalmology), Joseph Schlessinger(Weizmann Institute of Science)
Cited by 123Open Access
Abstract
The expression of epidermal growth factor (EGF) receptor in brain tumours of glial origin was studied at the protein, mRNA and genomic levels. Four out of 10 glioblastomas that overexpress EGF receptor also have gene amplification. The amplified genes appear to be rearranged, generating an aberrant mRNA in at least one of these tumours. Such receptor defects may be relevant to tumorigenesis of human glioblastomas.
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