Zika virus impairs growth in human neurospheres and brain organoids
Patrícia P. Garcez(Universidade Federal do Rio de Janeiro), Erick Correia Loiola(D’Or Institute for Research and Education), Rodrigo Madeiro da Costa(D’Or Institute for Research and Education), Luiza M. Higa(Universidade Federal do Rio de Janeiro), Pablo Trindade(D’Or Institute for Research and Education), Rodrigo Delvecchio(Universidade Federal do Rio de Janeiro), Juliana Nascimento(Universidade Estadual de Campinas (UNICAMP)), Rodrigo Brindeiro(Universidade Federal do Rio de Janeiro), Amílcar Tanuri(Universidade Federal do Rio de Janeiro), Stevens K. Rehen(Universidade Federal do Rio de Janeiro)
Cited by 1,203
Abstract
Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. We examined the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we showed that ZIKV targets human brain cells, reducing their viability and growth as neurospheres and brain organoids. These results suggest that ZIKV abrogates neurogenesis during human brain development.
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