Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype
Konrad Gabrusiewicz(The University of Texas MD Anderson Cancer Center), Benjamin A.T. Rodriguez(Baylor College of Medicine), Jun Wei(The University of Texas MD Anderson Cancer Center), Yuuri Hashimoto(The University of Texas MD Anderson Cancer Center), Luke M. Healy(Montreal Neurological Institute and Hospital), Sourindra N. Maiti(Pediatrics and Genetics), Ginu Thomas, Shouhao Zhou(Cancer Research And Biostatistics), Qianghu Wang, Ahmed Elakkad, Brandon Liebelt(The University of Texas MD Anderson Cancer Center), Nasser K. Yaghi(The University of Texas MD Anderson Cancer Center), Ravesanker Ezhilarasan, Neal Huang(The University of Texas MD Anderson Cancer Center), Jeffrey S. Weinberg(The University of Texas MD Anderson Cancer Center), Sujit S. Prabhu(The University of Texas MD Anderson Cancer Center), Ganesh Rao(The University of Texas MD Anderson Cancer Center), Raymond Sawaya(The University of Texas MD Anderson Cancer Center), Lauren A. Langford, Janet M. Bruner, Gregory N. Fuller, Amit Bar‐Or(Montreal Neurological Institute and Hospital), Wei Li(Baylor College of Medicine), Rivka R. Colen, Michael A. Curran, Krishna Bhat(The University of Texas MD Anderson Cancer Center), Jack P. Antel(McGill University), Laurence J.N. Cooper(Pediatrics and Genetics), Erik P. Sulman, Amy B. Heimberger(The University of Texas MD Anderson Cancer Center)
Cited by 454Open Access
Abstract
cells, microglia and MDSCs constituted a higher percentage of GAMs than did macrophages. GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype. Contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.
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