The Synthesis of Quinolone Natural Products from <i>Pseudonocardia</i> sp.
Flavia Salvaggio(University of Cambridge), James T. Hodgkinson(University of Cambridge), L. Carro(University of Cambridge), Stephen M. Geddis(University of Cambridge), Warren R. J. D. Galloway(University of Cambridge), Martin Welch(University of Cambridge), David R. Spring(University of Cambridge)
Cited by 29Open Access
Abstract
Abstract The synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp 2 –sp 3 Suzuki–Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores. The quinolones slowed growth of E. coli and S. aureus by inducing extended lag phases.
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