A Linkage Map of the Rat Genome Derived from Three F<sub>2</sub> Crosses
Marie Thérèse Bihoreau(University of Toledo Medical Center), Dominique Gauguier(University of Toledo Medical Center), Norihiro Kato(University of Toledo Medical Center), Gina Hyne(University of Toledo Medical Center), Klaus Lindpaintner(University of Toledo Medical Center), John P. Rapp(University of Toledo Medical Center), Michael R. James(University of Toledo Medical Center), G.M. Lathrop(University of Toledo Medical Center)
Cited by 141Open Access
Abstract
We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.
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