Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Minako Imamura(RIKEN Center for Integrative Medical Sciences), Atsushi Takahashi(National Cerebral and Cardiovascular Center), Toshimasa Yamauchi(The University of Tokyo), Kazuo Hara(Tokyo Medical University), Kazuki Yasuda(National Center for Global Health and Medicine), Niels Grarup(University of Copenhagen), Wei Zhao(University of Pennsylvania), Xu Wang(National University of Singapore), Alicia Huerta‐Chagoya(Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán), Cheng Hu(Shanghai Jiao Tong University), Sanghoon Moon(Korea National Institute of Health), Jirong Long(Vanderbilt University), Soo Heon Kwak(Seoul National University Hospital), Asif Rasheed(Center for Non-Communicable Diseases), Richa Saxena(Massachusetts General Hospital), Ronald C.W.(Chinese University of Hong Kong), Yukinori Okada(Tokyo Medical and Dental University), Minoru Iwata(University of Toyama), Jun Hosoe(The University of Tokyo), Nobuhiro Shojima(The University of Tokyo), Minaka Iwasaki(The University of Tokyo), Hayato Fujita(The University of Tokyo), Ken Suzuki(The University of Tokyo), John Danesh(University of Cambridge), Torben Jørgensen(University of Copenhagen), Marit E. Jørgensen(Steno Diabetes Centers), Daniel R. Witte(Aarhus University), Ivan Brandslund(University of Southern Denmark), Cramer Christensen(Lillebaelt Hospital), Torben Hansen(University of Copenhagen), Josep M. Mercader(Broad Institute), Jason Flannick(Broad Institute), Hortensia Moreno-Macías(Universidad Autónoma Metropolitana), Noël P. Burtt(Broad Institute), Rong Zhang(Shanghai Jiao Tong University), Young Jin Kim(Korea National Institute of Health), Wei Zheng(Vanderbilt University), Jai Rup Singh(Central University of Punjab), Claudia H.T. Tam(Chinese University of Hong Kong), Hiroshi Hirose(Keio University), Hiroshi Maegawa(Shiga University of Medical Science), Chikako Ito(Higashihiroshima Medical Center), Kohei Kaku(Kawasaki Medical School), Hirotaka Watada(Juntendo University), Yasushi Tanaka(St. Marianna University School of Medicine), Kazuyuki Tobe(University of Toyama), Ryuzo Kawamori(Juntendo University), Michiaki Kubo(RIKEN Center for Integrative Medical Sciences), Yoon Shin Cho(Hallym University), Juliana C.N. Chan(Chinese University of Hong Kong), Dharambir K. Sanghera(University of Oklahoma Health Sciences Center), Philippe Frossard(Center for Non-Communicable Diseases), Kyong Soo Park(Seoul National University), Xiao‐Ou Shu(Vanderbilt University), Bong-Jo Kim(Korea National Institute of Health), José C. Florez(Broad Institute), Teresa Tusié‐Luna(Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán), Weiping Jia(Shanghai Jiao Tong University), E Shyong Tai(National University of Singapore), Oluf Pedersen(University of Copenhagen), Danish Saleheen(Center for Non-Communicable Diseases), Shiro Maeda(University of the Ryukyus), Takashi Kadowaki(The University of Tokyo)
Nature Communications
January 28, 2016
10.1038/ncomms10531
Cited by 177Open Access
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Abstract

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

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