Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
John G. Doench(Broad Institute), Nicolò Fusi(Microsoft (United States)), Meagan E. Sullender(Broad Institute), Mudra Hegde(Broad Institute), Emma W Vaimberg(Broad Institute), Katherine Donovan(Broad Institute), Ian C. P. Smith(Broad Institute), Zuzana Tóthová(Broad Institute), Craig B. Wilen(Washington University in St. Louis), Robert C. Orchard(Washington University in St. Louis), Herbert W. Virgin(Washington University in St. Louis), Jennifer Listgarten(Microsoft (United States)), David E. Root(Broad Institute)
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