Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis
M.-L. Frémond(Assistance Publique – Hôpitaux de Paris), Philippe Pérot(Inserm), Erika Muth(Hydroquest (France)), Guilhem Cros(Délégation Paris 5), Marine Dumarest(Inserm), Nizar Mahlaoui(Human Genetic of Infectious Diseases), Danielle Seilhean(Sorbonne Université), Isabelle Desguerre(Hôpital Necker-Enfants Malades), C. Hébert(Hydroquest (France)), Nicole Corre-Catelin(Institut Pasteur), Bénédicte Neven(Sorbonne Paris Cité), Marc Lecuit(Biology of Infection), Stéphane Blanche(Sorbonne Paris Cité), Capucine Pïcard(Hôpital Necker-Enfants Malades), Marc Éloit(Inserm)
Cited by 136Open Access
Abstract
A boy with X-linked agammaglobulinemia experienced progressive global motor decline, cerebellar syndrome, and epilepsy. All standard polymerase chain reactions for neurotropic viruses were negative on cerebrospinal fluid and brain biopsy. Next-generation sequencing allowed fast identification of a new astrovirus strain (HAstV-VA1/HMO-C-PA), which led to tailor the patient's treatment, with encouraging clinical monitoring over 1 year.
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