Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

Qing Zhou; Hongying Wang; Daniella M. Schwartz; Monique Stoffels; Yong Hwan Park; Yuan Zhang; Dan Yang; Erkan Demirkaya; Masaki Takeuchi; Wanxia Li Tsai; Jonathan J. Lyons; Xiaomin Yu; Claudia Ouyang; Celeste Chen; David T. Chin; Kristien J.M. Zaal; Settara C. Chandrasekharappa; Eric P. Hanson; Zhen Yu; James C. Mullikin; Sarfaraz Hasni; Ingrid E. Wertz; Amanda K. Ombrello; Deborah L. Stone; Patrycja Hoffmann; Anne Jones; Beverly Barham; Helen L. Leavis; Annet van Royen-Kerkof; Cailin H. Sibley; Ezgi Deniz Batu; Ahmet Gül; Richard M. Siegel; Manfred Boehm; Joshua D. Milner; Seza Özen; Massimo Gadina; JaeJin Chae; Ronald M. Laxer; Daniel L. Kastner; Ivona Aksentijevich

doi:10.1038/ng.3459

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

Qing Zhou(National Human Genome Research Institute), Hongying Wang(National Human Genome Research Institute), Daniella M. Schwartz(National Institute of Arthritis and Musculoskeletal and Skin Diseases), Monique Stoffels(National Human Genome Research Institute), Yong Hwan Park(National Human Genome Research Institute), Yuan Zhang(National Institute of Allergy and Infectious Diseases), Dan Yang(National Heart Lung and Blood Institute), Erkan Demirkaya(Turkish Armed Forces), Masaki Takeuchi(National Human Genome Research Institute), Wanxia Li Tsai(National Institute of Arthritis and Musculoskeletal and Skin Diseases), Jonathan J. Lyons(National Institute of Allergy and Infectious Diseases), Xiaomin Yu(National Institute of Allergy and Infectious Diseases), Claudia Ouyang(National Institute of Arthritis and Musculoskeletal and Skin Diseases), Celeste Chen(National Human Genome Research Institute), David T. Chin(National Human Genome Research Institute), Kristien J.M. Zaal(National Institute of Arthritis and Musculoskeletal and Skin Diseases), Settara C. Chandrasekharappa(National Human Genome Research Institute), Eric P. Hanson(National Institute of Arthritis and Musculoskeletal and Skin Diseases), Zhen Yu(National Heart Lung and Blood Institute), James C. Mullikin(National Human Genome Research Institute), Sarfaraz Hasni(National Institute of Arthritis and Musculoskeletal and Skin Diseases), Ingrid E. Wertz(Molecular Oncology (United States)), Amanda K. Ombrello(National Human Genome Research Institute), Deborah L. Stone(National Human Genome Research Institute), Patrycja Hoffmann(National Human Genome Research Institute), Anne Jones(National Human Genome Research Institute), Beverly Barham(National Human Genome Research Institute), Helen L. Leavis(University Medical Center Utrecht), Annet van Royen-Kerkof(University Medical Center Utrecht), Cailin H. Sibley(Oregon Health & Science University), Ezgi Deniz Batu(Hacettepe University), Ahmet Gül(Istanbul University), Richard M. Siegel(National Institute of Arthritis and Musculoskeletal and Skin Diseases), Manfred Boehm(National Heart Lung and Blood Institute), Joshua D. Milner(National Institute of Allergy and Infectious Diseases), Seza Özen(Hacettepe University), Massimo Gadina(National Institute of Arthritis and Musculoskeletal and Skin Diseases), JaeJin Chae(National Human Genome Research Institute), Ronald M. Laxer(University of Toronto), Daniel L. Kastner(National Human Genome Research Institute), Ivona Aksentijevich(National Human Genome Research Institute)

Nature Genetics

December 7, 2015

10.1038/ng.3459

Cited by 626Open Access

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