MOLECULAR GENETICS OF HUMAN VISUAL PIGMENTS

Abstract

INTRODUCTION 403 COLOR VISION ........ . ... . ...... ... . ...... 405 RED AND GREEN PIGMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 406 Psychophysics of Red/Green Color Blindness ... . .... . . , 406 Molecular Genetics of Red/Green Color Blindness . . . . . . . . . . . . . . . . . . . . 407 Variation in Normal Color Vision ..... . . 409 Blue Cone Monochromacy . 412 THE BLUE PIGMENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415 Psychophysics of Tritanopia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415 Molecular Genetics of Tritanopia ..... . , 415 RHODOPSIN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 416 Inherited Defects in Rod Vision ...... . 416 Rhodopsin Mutations in Retinitis Pigmentosa . . . .. . . . . . . . . . . . . . .. . . . 417 Biochemical Characteristics of Mutant Rhodopsins . . . . . . . . . . . . . . . . . . . . 418 PERSPECTIVE . 420