RETRACTED: An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo
Tianzhu Yu(Centre National de la Recherche Scientifique), Xiaoxuan Liu(Centre National de la Recherche Scientifique), Anne‐Laure Bolcato‐Bellemin(Transgene (France)), Yang Wang(Centre National de la Recherche Scientifique), Cheng Liu, Patrick Erbacher(Transgene (France)), Fanqi Qu(Wuhan University), Palma Rocchi(Centre National de la Recherche Scientifique), Jean‐Paul Behr(Centre National de la Recherche Scientifique), Ling Peng(Centre National de la Recherche Scientifique)
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Abstract
An amphiphilic dendrimer bearing a hydrophobic alkyl chain and hydrophilic poly(amidoamine) dendrons is able to combine the advantageous features of lipid and dendrimer vectors to deliver a heat shock protein 27 siRNA and produce potent gene silencing and anticancer activity in vitro and in vivo in a prostate cancer model. This dendrimer can be used alternatively for treating various diseases.
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