NetPath: a public resource of curated signal transduction pathways
Kumaran Kandasamy(Johns Hopkins University), S Sujatha Mohan(Institute of Bioinformatics), Rajesh Raju(Kuvempu University), Shivakumar Keerthikumar(Institute of Bioinformatics), Ghantasala S. Sameer Kumar(Institute of Bioinformatics), Abhilash K Venugopal(Institute of Bioinformatics), Deepthi Telikicherla(Institute of Bioinformatics), J. Daniel Navarro(Institute of Bioinformatics), Suresh Mathivanan(Institute of Bioinformatics), C. Pecquet(RIKEN Center for Integrative Medical Sciences), Sashi Kanth Gollapudi(Institute of Bioinformatics), Sudhir Gopal Tattikota(Institute of Bioinformatics), Shyam Mohan(Institute of Bioinformatics), Hariprasad Padhukasahasram(Institute of Bioinformatics), Yashwanth Subbannayya(Institute of Bioinformatics), Renu Goel(Institute of Bioinformatics), Harrys K.C. Jacob(Johns Hopkins University), Jun Zhong(Johns Hopkins University), Raja Sekhar Nirujogi(Institute of Bioinformatics), Vishalakshi Nanjappa(Institute of Bioinformatics), Lavanya Balakrishnan(Institute of Bioinformatics), Roopashree Subbaiah(Institute of Bioinformatics), YL Ramachandra(Kuvempu University), B. A. Rahiman(Kuvempu University), Thottethodi Subrahmanya Keshava Prasad(Institute of Bioinformatics), Jian-Xin Lin(National Heart Lung and Blood Institute), Jon C. D. Houtman(University of Iowa), Stephen Desiderio(Johns Hopkins University), Jean‐Christophe Renauld(Ludwig Cancer Research), Stefan N. Constantinescu(Ludwig Cancer Research), Osamu Ohara(Kazusa DNA Research Institute), Toshio Hirano(RIKEN Center for Integrative Medical Sciences), Masato Kubo(Tokyo University of Science), Sujay Singh(IMGENEX India (India)), Purvesh Khatri(Wayne State University), Sorin Drăghici(Wayne State University), Gary D. Bader(Memorial Sloan Kettering Cancer Center), Chris Sander(Memorial Sloan Kettering Cancer Center), Warren J. Leonard(National Heart Lung and Blood Institute), Akhilesh Pandey(Johns Hopkins University)
Cited by 532Open Access
Abstract
Abstract We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.
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