The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration

Perminder S. Sachdev(Dementia Collaborative Research Centres), Darren M. Lipnicki(UNSW Sydney), Nicole A. Kochan(UNSW Sydney), John D. Crawford(UNSW Sydney), Anbupalam Thalamuthu(UNSW Sydney), Gavin Andrews(UNSW Sydney), Carol Brayne(University of Cambridge), Fiona E. Matthews(Newcastle University), Blossom C. M. Stephan(Newcastle University), Richard B. Lipton(Yeshiva University), Mindy J. Katz(Albert Einstein College of Medicine), Karen Ritchie(Inserm), Isabelle Carrière(Université de Montpellier), Marie‐Laure Ancelin(Neuropsychiatrie : Recherche Epidemiologique et Clinique), Linda Lam(Chinese University of Hong Kong), Candy Wong(Tai Po Hospital), Ada W. T. Fung(Chinese University of Hong Kong), Antonio Guaita(Fondazione Golgi Cenci), Roberta Vaccaro(Fondazione Golgi Cenci), Annalisa Davin(Fondazione Golgi Cenci), Mary Ganguli(University of Pittsburgh), Hiroko H. Dodge(University of Michigan–Ann Arbor), Tiffany F. Hughes(University of Pittsburgh), Kaarin J. Anstey(Australian National University), Nicolas Cherbuin(Australian National University), Peter Butterworth(Australian National University), Tze Pin Ng(National University of Singapore), Qi Gao(National University of Singapore), Simone Reppermund(UNSW Sydney), Henry Brodaty(Dementia Collaborative Research Centres), Nicole Schupf(Columbia University), Jennifer J. Manly(Columbia University), Yaakov Stern(Columbia University), Antonio Lobo(Centro de Investigación Biomédica en Red de Salud Mental), Raúl López‐Antón(Centro de Investigación Biomédica en Red), Javier Santabárbara(Centro de Investigación Biomédica en Red de Salud Mental)
PLoS ONE
November 5, 2015
10.1371/journal.pone.0142388
Cited by 380Open Access
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Abstract

BACKGROUND: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). METHODS: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. RESULTS: The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01). CONCLUSION: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

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