Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
Martin Münzel(Center for Integrated Protein Science Munich), Daniel Globisch(Center for Integrated Protein Science Munich), Tobias Brückl(Ludwig-Maximilians-Universität München), Mirko Wagner(Center for Integrated Protein Science Munich), Veronika Welzmiller(Ludwig-Maximilians-Universität München), Stylianos Michalakis(Center for Integrated Protein Science Munich), Markus Müller(Center for Integrated Protein Science Munich), Martin Biel(Center for Integrated Protein Science Munich), Thomas Carell(Center for Integrated Protein Science Munich)
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Abstract
Mind over matter: LC-MS has allowed the amount of the post-replicatively formed DNA base 5-hydroxymethylcytosine (see picture; left) to be quantified in brain tissue. The nucleoside is most abundant in areas that are associated with higher cognitive functions, and its content in mouse hippocampi seems to increase with age. The new method enables hydroxymethylcytosine to be quantified with unprecedented accuracy.
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