The completion of the Mammalian Gene Collection (MGC)
The MGC Project Team(National Institutes of Health), Gary Temple(National Institutes of Health), Daniela S. Gerhard(National Institutes of Health), Rebekah S. Rasooly(National Institutes of Health), Elise A. Feingold(National Institutes of Health), Peter J. Good(National Institutes of Health), Cristen Robinson(National Institutes of Health), Allison Mandich(National Institutes of Health), Jeffrey G. Derge(National Cancer Institute), Jeanne Lewis(National Cancer Institute), Debonny Shoaf(National Institutes of Health), Francis S. Collins(National Institutes of Health), Wonhee Jang(National Center for Biotechnology Information), Lukas Wagner(National Center for Biotechnology Information), Carolyn M. Shenmen(National Center for Biotechnology Information), Leonie Misquitta(National Cancer Institute), Carl F. Schaefer(National Cancer Institute), Kenneth H. Buetow(National Institutes of Health), Tom I. Bonner(National Center for Biotechnology Information), Linda Yankie(National Center for Biotechnology Information), Ming Ward(National Center for Biotechnology Information), Lon Phan(National Center for Biotechnology Information), Alex Astashyn(National Center for Biotechnology Information), Garth Brown(National Center for Biotechnology Information), Catherine M. Farrell(National Center for Biotechnology Information), Jennifer Hart(National Center for Biotechnology Information), Melissa Landrum(National Center for Biotechnology Information), B. Maidak(National Center for Biotechnology Information), Michael R. Murphy(National Center for Biotechnology Information), Terence D. Murphy(National Center for Biotechnology Information), Bhanu Rajput(National Center for Biotechnology Information), Lillian D. Riddick(National Center for Biotechnology Information), David Webb(National Center for Biotechnology Information), Janet A. Weber(National Center for Biotechnology Information), Wendy Wu(National Center for Biotechnology Information), Kim D. Pruitt(National Center for Biotechnology Information), Donna Maglott(Cornell University), Adam Siepel(Cornell University), Broňa Brejová(University of California, Santa Cruz), Mark Diekhans(University of California, Santa Cruz), Rachel Harte(University of California, Santa Cruz), Robert Baertsch(University of California, Santa Cruz), Jim Kent(University of California, Santa Cruz), David Haussler(University of California, Santa Cruz), Michael R. Brent(Washington University in St. Louis), Laura Langton(Washington University in St. Louis), Charles L.G. Comstock(Washington University in St. Louis), Michael Stevens(Shanghai Jiao Tong University), Chaochun Wei(Washington University in St. Louis), Marijke J. van Baren(Washington University in St. Louis), Kourosh Salehi‐Ashtiani(Dana-Farber Cancer Institute), Ryan R. Murray(Dana-Farber Cancer Institute), Lila Ghamsari(Dana-Farber Cancer Institute), Elizabeth Mello(Dana-Farber Cancer Institute), Chenwei Lin(Lawrence Livermore National Laboratory), Christa Pennacchio(Lawrence Livermore National Laboratory), Kirsten Schreiber(Lawrence Livermore National Laboratory), Nicole Shapiro(Lawrence Livermore National Laboratory), Amber Marsh(Lawrence Livermore National Laboratory), Elizabeth Pardes(Lawrence Livermore National Laboratory), Troy Moore(HudsonAlpha Institute for Biotechnology), Anita Lebeau(HudsonAlpha Institute for Biotechnology), Mike Muratet(Thermo Fisher Scientific (United States)), Blake A. Simmons(Thermo Fisher Scientific (United States)), David Kloske(Thermo Fisher Scientific (United States)), Stephanie Sieja(HudsonAlpha Institute for Biotechnology), James R. Hudson(National Institutes of Health), Praveen Sethupathy(National Institutes of Health), Michael Brownstein(United States Patent and Trademark Office), Narayan Bhat(Medical College of Wisconsin), Joseph Lazar(Medical College of Wisconsin), Howard J. Jacob(Medical College of Wisconsin), C. E. Gruber(ID Genomics (United States)), Mark R. Smith(Baylor College of Medicine), John D. McPherson(Baylor College of Medicine), Angela Garcia(Baylor College of Medicine), Preethi H. Gunaratne(Baylor College of Medicine), Jiaqian Wu(Baylor College of Medicine), Donna M. Muzny(Baylor College of Medicine), Richard A. Gibbs(National Institutes of Health), Alice Young(National Institutes of Health), Gerard G. Bouffard(National Institutes of Health), Robert W. Blakesley(National Institutes of Health), Jim Mullikin(National Institutes of Health), Eric D. Green(FX Palo Alto Laboratory), Mark Dickson(FX Palo Alto Laboratory), Álex Rodríguez(HudsonAlpha Institute for Biotechnology), Jane Grimwood(HudsonAlpha Institute for Biotechnology), Jeremy Schmutz(HudsonAlpha Institute for Biotechnology), R Myers(BC Cancer Agency), Martin Hirst(BC Cancer Agency), Thomas Zeng(BC Cancer Agency), Kane Tse(BC Cancer Agency), Michelle Moksa(BC Cancer Agency), Merinda Deng(BC Cancer Agency), Kevin Ma(BC Cancer Agency), Diana Mah(BC Cancer Agency), Johnson Pang(BC Cancer Agency), Greg Taylor(BC Cancer Agency), Eric Chuah(BC Cancer Agency), Athena Deng(BC Cancer Agency), Keith Fichter(BC Cancer Agency), Anne Go(BC Cancer Agency), Stephanie J. Lee(BC Cancer Agency), Jing Wang(BC Cancer Agency), Malachi Griffith(BC Cancer Agency), Ryan D. Morin(BC Cancer Agency), Richard A. Moore(BC Cancer Agency), Michael Mayo(BC Cancer Agency), Sarah Munro(BC Cancer Agency), Susan Wagner(BC Cancer Agency), Steven J.M. Jones(BC Cancer Agency), Robert A. Holt(BC Cancer Agency), Marco A. Marra(BC Cancer Agency), Lu Sun(GeneCopoeia (United States)), Shuwei Yang(GeneCopoeia (United States)), James Hartigan(Becker College), Marcus Graf(University of Regensburg), Ralf Wagner(University of Regensburg), Stanley Letovksy(Analog Devices (United States)), Jacqueline C. Pulido(Analog Devices (United States)), Keith Robison(Analog Devices (United States)), Dominic Esposito(Protein Express (United States)), James L. Hartley(Protein Express (United States)), Vanessa Wall(Protein Express (United States)), Ralph F. Hopkins(Protein Express (United States)), Osamu Ohara(German Cancer Research Center), Stefan Wiemann(German Cancer Research Center)
Cited by 147Open Access
Abstract
Since its start, the Mammalian Gene Collection (MGC) has sought to provide at least one full-protein-coding sequence cDNA clone for every human and mouse gene with a RefSeq transcript, and at least 6200 rat genes. The MGC cloning effort initially relied on random expressed sequence tag screening of cDNA libraries. Here, we summarize our recent progress using directed RT-PCR cloning and DNA synthesis. The MGC now contains clones with the entire protein-coding sequence for 92% of human and 89% of mouse genes with curated RefSeq (NM-accession) transcripts, and for 97% of human and 96% of mouse genes with curated RefSeq transcripts that have one or more PubMed publications, in addition to clones for more than 6300 rat genes. These high-quality MGC clones and their sequences are accessible without restriction to researchers worldwide.
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