Self‐Promoted Nucleophilic Addition of Hexafluoro‐2‐propanol to Vinyl Ethers
Andrea Di Salvo(Institut Galien Paris-Saclay), Marc David(Institut Galien Paris-Saclay), Benoı̂t Crousse(Institut Galien Paris-Saclay), Danièle Bonnet‐Delpon(Institut Galien Paris-Saclay)
Cited by 35
Abstract
Abstract In spite of its low nucleophilicity, hexafluoro‐2‐propanol easily adds to vinyl ethers, without catalyst, to afford a range of hexafluoroisopropyloxy acetals. This addition reaction also occurred in the presence of a competitive, more nucleophilic alcohol. Kinetic studies showed the importance of hydrogen bond parameters in the rate and course of the reaction.
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