Characterization of Mammalian Selenoproteomes
Gregory V. Kryukov(University of Nebraska–Lincoln), Sergi Castellano(University of Nebraska–Lincoln), Sergey V. Novoselov(University of Nebraska–Lincoln), Alexey V. Lobanov(University of Nebraska–Lincoln), Omid Zehtab(University of Nebraska–Lincoln), Roderic Guigó(University of Nebraska–Lincoln), Vadim N. Gladyshev(University of Nebraska–Lincoln)
Cited by 2,360
Abstract
In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.
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