TEAD mediates YAP-dependent gene induction and growth control

Bin Zhao(University of Michigan), Xin Ye(Pennsylvania State University), Jindan Yu(University of Michigan), Li Li(University of Michigan), Weiquan Li(University of Michigan), Siming Li(University of Michigan), Jianjun Yu(University of Michigan), Jiandie D. Lin(University of Michigan), Cun-Yu Wang(University of California, Los Angeles), Arul M. Chinnaiyan(University of Michigan), Zhi-Chun Lai(Pennsylvania State University), Kun‐Liang Guan(University of California San Diego)
Genes & Development
June 25, 2008
10.1101/gad.1664408
Cited by 2,513Open Access
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Abstract

The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.

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