AN OUTBREAK OF DENGUE VIRUS SEROTYPE 1 INFECTION IN CIXI, NINGBO, PEOPLE’S REPUBLIC OF CHINA, 2004, ASSOCIATED WITH A TRAVELER FROM THAILAND AND HIGH DENSITY OF AEDES ALBOPICTUS

Guozhang Xu(Ningbo Center for Disease Control and Prevention), Hongjun Dong(Ningbo Center for Disease Control and Prevention), Nanfeng Shi(Ningbo Center for Disease Control and Prevention), Shijian Liu(Ningbo Center for Disease Control and Prevention), Aiming Zhou(Ningbo Center for Disease Control and Prevention), Zhihua Cheng(Ningbo Center for Disease Control and Prevention), Guohua Chen(Ningbo Center for Disease Control and Prevention), Jianyi Liu(Ningbo Center for Disease Control and Prevention), Ting Fang(Ningbo Center for Disease Control and Prevention), Hongwei Zhang(Ningbo Center for Disease Control and Prevention), Chunying Gu(Ningbo Center for Disease Control and Prevention), Xiao-jie Tan(Ningbo Center for Disease Control and Prevention), Ye JianJie(Ningbo Center for Disease Control and Prevention), SHUYUN XIE(Ningbo Center for Disease Control and Prevention), Guangwen Cao(Ningbo Center for Disease Control and Prevention)
American Journal of Tropical Medicine and Hygiene
June 1, 2007
10.4269/ajtmh.2007.76.1182
Cited by 110Open Access
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Abstract

Autochthonous dengue infections have not been reported in Ningbo, People's Republic of China since 1929. In August-October 2004, an outbreak of dengue fever was confirmed in Xiaolin, Cixi, Ningbo. Of 83 cases reported, 68 were laboratory confirmed. Fifty-three percent (34 of 64) of the cases had IgM antibodies to dengue virus. Dengue virus serotype-1 was isolated from two cases. The outbreak was linked to a traveler who returned from Thailand. Phylogenetic analysis showed that the Ningbo isolate was closely associated to strains from Thailand. Prevalence of dengue-specific IgG in asymptomatic residents was significantly higher in the epidemic-stricken area than in a control area. High density of Aedes albopictus, which resulted from waterlogging caused by Typhoon Rananim and lifestyle of local residents, was responsible for rapid spread of the virus. Eradication of mosquito infestation might interrupt transmission. This outbreak underscores the importance of maintaining surveillance and control of potential vectors for the control of emerging infectious diseases.

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