Tauopathy-like Abnormalities and Neurologic Deficits in Mice Immunized With Neuronal Tau Protein
Hanna Rosenmann(AHEPA University Hospital), Nikolaos Grigoriadis(AHEPA University Hospital), Dimitrios Karussis(AHEPA University Hospital), Moran Boimel(AHEPA University Hospital), Olga Touloumi(AHEPA University Hospital), Haim Ovadia(AHEPA University Hospital), Oded Abramsky(AHEPA University Hospital)
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Abstract
These results provide a link between tau autoimmunity and tauopathy-like abnormalities and indicate potential dangers of using tau for immunotherapy. This experimental autoimmune tauopathy-like model is due to a pathogenic immune response against an intraneuronal antigen and is not related to myelin antigens.
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