Selective Extraction of Peptides from Human Plasma by Highly Ordered Mesoporous Silica Particles for Peptidome Analysis
Ruijun Tian(Chinese Academy of Sciences), He Zhang(Dalian Institute of Chemical Physics), Mingliang Ye(Chinese Academy of Sciences), Xiaogang Jiang(Chinese Academy of Sciences), Lianghai Hu(Chinese Academy of Sciences), Xin Li(Chinese Academy of Sciences), Xinhe Bao(Dalian Institute of Chemical Physics), Hanfa Zou(Chinese Academy of Sciences)
Cited by 185
Abstract
Pores for effect: Silica particles with a pore size of 20.5 Å (see TEM image) are effective for enriching peptides in human plasma over a wide range of molecular weights from 1 to 12 kDa, while repelling most other plasma proteins outside. The pore structure of the material makes it superior for peptide enrichment compared to adsorbent- and ultrafiltration-based methods.
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