Randomised trials in surgery: problems and possible solutions
Peter McCulloch(University of Liverpool), Irving Taylor(University College London), Mitsuru Sasako(National Cancer Centre Japan), Bryony Lovett(Basildon Hospital), Damian Griffin(Nuffield Orthopaedic Centre)
Cited by 760Open Access
Abstract
The quality and quantity of randomised trials of surgical techniques is acknowledged to be limited. According to Peter McCulloch and colleagues, however, some aspects of surgery present special difficulties for randomised trials. In this article they analyse what these difficulties are and propose some solutions for improving the standards of clinical research in surgery.
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