Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
Tim Wiltshire(Scripps Research Institute), Mathew T. Pletcher(Scripps Research Institute), Serge Batalov(Scripps Research Institute), S. Whitney Barnes(Scripps Research Institute), Lisa M. Tarantino(Scripps Research Institute), M. Cooke(Scripps Research Institute), Hua Wu(Scripps Research Institute), Kevin J. Smylie(Scripps Research Institute), Andrey Santrosyan(Scripps Research Institute), Neal G. Copeland(Scripps Research Institute), Nancy A. Jenkins(Scripps Research Institute), Francis Kalush(Scripps Research Institute), Richard Mural(Scripps Research Institute), Richard Glynne(Scripps Research Institute), Steve A. Kay(Scripps Research Institute), Mark D. Adams(Scripps Research Institute), Colin Fletcher(Scripps Research Institute)
Cited by 230Open Access
Abstract
The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome.