Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

Bin Shen; Wensheng Zhang; Jun Zhang; Jiankui Zhou; Jian-Ying Wang; Li Chen; Lu Wang; Alex Hodgkins; Vivek Iyer; Xingxu Huang; William C. Skarnes

doi:10.1038/nmeth.2857

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

Bin Shen(Model Animal Research Center), Wensheng Zhang(Wellcome Sanger Institute), Jun Zhang(Model Animal Research Center), Jiankui Zhou(Model Animal Research Center), Jian-Ying Wang(Model Animal Research Center), Li Chen(Model Animal Research Center), Lu Wang(Chinese Academy of Sciences), Alex Hodgkins(Wellcome Sanger Institute), Vivek Iyer(Wellcome Sanger Institute), Xingxu Huang(Model Animal Research Center), William C. Skarnes(Wellcome Sanger Institute)

Nature Methods

March 2, 2014

10.1038/nmeth.2857

Cited by 838

Abstract

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