CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms

Sara C. Meyer; Matthew D. Keller; Sophia Chiu; Priya Koppikar; Olga A. Guryanova; Franck Rapaport; Ke Xu; Katia Manova; Dmitry Pankov; Richard J. O’Reilly; Maria Kleppe; Anna Sophia McKenney; Alan H. Shih; Kaitlyn Shank; Jihae Ahn; Eftymia Papalexi; Barbara Spitzer; Nick Socci; Agnès Viale; Emeline Mandon; Nicolas Ebel; Rita Andraos; Joëlle Rubert; Ernesta Dammassa; Vincent Romanet; Arno Dölemeyer; Michael Zender; Melanie Heinlein; Raajit K. Rampal; Rona Singer Weinberg; Ronald Hoffman; William R. Sellers; Francesco Hofmann; Masato Murakami; Fabienne Baffert; Christoph Gaul; Thomas Radimerski; Ross L. Levine

doi:10.1016/j.ccell.2015.06.006

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms

Sara C. Meyer(Memorial Sloan Kettering Cancer Center), Matthew D. Keller(Memorial Sloan Kettering Cancer Center), Sophia Chiu(Memorial Sloan Kettering Cancer Center), Priya Koppikar(Memorial Sloan Kettering Cancer Center), Olga A. Guryanova(Memorial Sloan Kettering Cancer Center), Franck Rapaport(Memorial Sloan Kettering Cancer Center), Ke Xu(Memorial Sloan Kettering Cancer Center), Katia Manova(Memorial Sloan Kettering Cancer Center), Dmitry Pankov(Memorial Sloan Kettering Cancer Center), Richard J. O’Reilly(Memorial Sloan Kettering Cancer Center), Maria Kleppe(Memorial Sloan Kettering Cancer Center), Anna Sophia McKenney(Memorial Sloan Kettering Cancer Center), Alan H. Shih(Memorial Sloan Kettering Cancer Center), Kaitlyn Shank(Memorial Sloan Kettering Cancer Center), Jihae Ahn(Memorial Sloan Kettering Cancer Center), Eftymia Papalexi(Memorial Sloan Kettering Cancer Center), Barbara Spitzer(Memorial Sloan Kettering Cancer Center), Nick Socci(Memorial Sloan Kettering Cancer Center), Agnès Viale(Molecular Oncology (United States)), Emeline Mandon(Novartis (Switzerland)), Nicolas Ebel(Novartis Institutes for BioMedical Research), Rita Andraos(Novartis Institutes for BioMedical Research), Joëlle Rubert(Novartis Institutes for BioMedical Research), Ernesta Dammassa(Novartis (Switzerland)), Vincent Romanet(Novartis (Switzerland)), Arno Dölemeyer(Novartis Institutes for BioMedical Research), Michael Zender(Novartis (Switzerland)), Melanie Heinlein(Novartis (Switzerland)), Raajit K. Rampal(Memorial Sloan Kettering Cancer Center), Rona Singer Weinberg(New York Blood Center), Ronald Hoffman(Mount Sinai Hospital), William R. Sellers(Novartis (United States)), Francesco Hofmann(Novartis (Switzerland)), Masato Murakami(Novartis Institutes for BioMedical Research), Fabienne Baffert(Novartis Institutes for BioMedical Research), Christoph Gaul(Novartis Institutes for BioMedical Research), Thomas Radimerski(Novartis Institutes for BioMedical Research), Ross L. Levine(Memorial Sloan Kettering Cancer Center)

Cancer Cell

July 1, 2015

10.1016/j.ccell.2015.06.006

Cited by 155

Abstract

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