Isolation and Characterization of a New T-Even Bacteriophage, CEV1, and Determination of Its Potential To Reduce <i>Escherichia coli</i> O157:H7 Levels in Sheep
Raúl R. Raya(Texas College), Peter Varey(The Evergreen State College), Rebecca A. Oot(The Evergreen State College), Michael R. Dyen(The Evergreen State College), Todd R. Callaway(Texas College), Tom S. Edrington(Texas College), Elizabeth Kutter(The Evergreen State College), A.D. Brabban(The Evergreen State College)
Cited by 160Open Access
Abstract
Bacteriophage CEV1 was isolated from sheep resistant to Escherichia coli O157:H7 colonization. In vitro, CEV1 efficiently infected E. coli O157:H7 grown both aerobically and anaerobically. In vivo, sheep receiving a single oral dose of CEV1 showed a 2-log-unit reduction in intestinal E. coli O157:H7 levels within 2 days compared to levels in the controls.
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