Hundreds of variants clustered in genomic loci and biological pathways affect human height

Hana Lango Allen; Karol Estrada; Guillaume Lettre; Sonja I. Berndt; Michael N. Weedon; Fernando Rivadeneira; Cristen J. Willer; Anne Jackson; Sailaja Vedantam; Soumya Raychaudhuri; Teresa Ferreira; Andrew R. Wood; Robert J. Weyant; Ayellet V. Segrè; Elizabeth K. Speliotes; Eleanor Wheeler; Nicole Soranzo; Ju‐Hyun Park; Jian Yang; Daníel F. Guðbjartsson; Nancy L. Heard‐Costa; Joshua C. Randall; Lu Qi; Albert V. Smith; Reedik Mägi; Tomi Pastinen; Liming Liang; Iris M. Heid; Jian’an Luan; Guðmar Þorleifsson; Thomas W. Winkler; Michael E. Goddard; Ken Sin Lo; Cameron D. Palmer; Tsegaselassie Workalemahu; Yurii S. Aulchenko; Åsa Johansson; M. Carola Zillikens; Mary F. Feitosa; Tõnu Esko; Toby Johnson; Shamika Ketkar; Peter Kraft; Massimo Mangino; Inga Prokopenko; Devin Absher; Eva Albrecht; Florian Ernst; Nicole L. Glazer; Caroline Hayward; Jouke‐Jan Hottenga; Kevin B. Jacobs; Joshua W. Knowles; Zoltán Kutalik; Keri L. Monda; Ozren Polašek; Michael Preuß; Nigel W. Rayner; Neil R. Robertson; Valgerður Steinthórsdóttir; Jonathan P. Tyrer; Benjamin F. Voight; Fredrik Wiklund; Jianfeng Xu; Wei Zhao; Dale R. Nyholt; Niina Pellikka; Markus Perola; John R. B. Perry; Ida Surakka; Mari‐Liis Tammesoo; Elizabeth L. Altmaier; Najaf Amin; Thor Aspelund; Tushar Bhangale; Gabrielle Boucher; Daniel I. Chasman; Constance Chen; Lachlan Coin; Matthew N. Cooper; Anna Dixon; Quince Gibson; Elin Grundberg; Ke Hao; Juhani Junttila; Lee M. Kaplan; Johannes Kettunen; Inke R. König; Tony Kwan; Robert Lawrence; Douglas F. Levinson; Mattias Lorentzon; Barbara McKnight; Andrew P. Morris; Martina Müller‐Nurasyid; Julius S. Ngwa; Shaun Purcell; Suzanne Rafelt; Rany M. Salem; Erika Salvi; Serena Sanna; Jianxin Shi; Ulla Sovio; John R. Thompson; Michael C. Turchin; Liesbeth Vandenput; Dominique J. Verlaan; Véronique Vitart; Charles C. White; Andreas Ziegler; Peter Almgren; Anthony J. Balmforth; Harry Campbell; Lorena Citterio; Alessandro De Grandi; Anna F. Dominiczak; Jubao Duan; Paul Elliott; Roberto Elosúa; Johan G. Eriksson; Nelson B. Freimer; Eco J. C. de Geus; Nicola Glorioso; Haiqing Shen; Anna-Liisa Hartikainen; Aki S. Havulinna; Andrew A. Hicks; Jennie Hui; Wilmar Igl; Thomas Illig; Antti Jula; Eero Kajantie; Tuomas O. Kilpeläinen; Markku Koiranen; Ivana Kolčić; Seppo Koskinen; Péter Kovács; Jaana Laitinen; Jianjun Liu; Marja‐Liisa Lokki; Ana Marušić; Andrea Maschio; Thomas Meitinger; Antonella Mulas; Guillaume Paré; Alex Parker; John F. Peden; Astrid Petersmann; Irene Pichler; Kirsi H. Pietiläinen; Anneli Pouta; Martin Ridderstråle; Jerome I. Rotter; Jennifer G. Sambrook; Alan R. Sanders; Carsten Oliver Schmidt; Juha Sinisalo; Jan Smit; Heather M. Stringham; G. Bragi Walters; Elisabeth Widén; Sarah H. Wild; Gonneke Willemsen; Laura Zagato; Lina Zgaga; Paavo Zitting; Helene Alavere; Martin Farrall; Wendy L. McArdle; Mari Nelis; Marjolein J. Peters; Samuli Ripatti; Joyce B. J. van Meurs; Katja K.H. Aben; Kristin Ardlie; J. Beckmann; John Beilby; Richard N. Bergman; Sven Bergmann; Francis S. Collins; Daniele Cusi; Martin den Heijer; Guðný Eiríksdóttir; Pablo V. Gejman; Alistair S. Hall; Anders Hamsten; Heikki V. Huikuri; Carlos Iribarren; Mika Kähönen; Jaakko Kaprio; Sekar Kathiresan; Lambertus A. Kiemeney; Thomas Köcher; Lenore J. Launer; Terho Lehtimäki; Olle Melander; Tom Mosley; Arthur W. Musk; Markku S. Nieminen; Christopher J. O’Donnell; Claes Ohlsson; Ben A. Oostra; Lyle J. Palmer; Olli T. Raitakari; Paul M. Ridker; John D. Rioux; Aila Rissanen; Carlo Rivolta; Heribert Schunkert; Alan R. Shuldiner; David S. Siscovick; Michael Stümvoll; Anke Tönjes; Jaakko Tuomilehto; Gert-Jan van Ommen; Jorma Viikari; Andrew C. Heath; Nicholas G. Martin; Grant W. Montgomery; Michael A. Province; Manfred Kayser; Alice M. Arnold; Larry D. Atwood; Eric Boerwinkle; Stephen J. Chanock; Panos Deloukas; Christian Gieger; Henrik Grönberg; Per Hall; Andrew T. Hattersley; Christian Hengstenberg; Wolfgang Hoffman; G.M. Lathrop; Veikko Salomaa; Stefan Schreiber; Manuela Uda; Dawn Waterworth; Alan F. Wright; Themistocles L. Assimes; Inês Barroso; Albert Hofman; Karen L. Mohlke; Dorret I. Boomsma; Mark J. Caulfield; L. Adrienne Cupples; Jeanette Erdmann; Caroline S. Fox; Vilmundur Guðnason; Ulf Gyllensten; Tamara B. Harris; Richard B. Hayes; Marjo‐Riitta Järvelin; Vincent Mooser; Patricia B. Munroe; Willem H. Ouwehand; Brenda W.J.H. Penninx; Peter P. Pramstaller; Thomas Quertermous; Igor Rudan; Nilesh J. Samani; Timothy D. Spector; Henry Völzke; Hugh Watkins; James F. Wilson; Leif Groop; Talin Haritunians; Frank B. Hu; Robert C. Kaplan; Andres Metspalu; Kari E. North; David Schlessinger; Nicholas J. Wareham; David J. Hunter; Jeffrey R. O’Connell; David P. Strachan; H.‐Erich Wichmann; Ingrid B. Borecki; Cornelia M. van Duijn; Eric E. Schadt; Unnur Þorsteinsdóttir; Leena Peltonen; André G. Uitterlinden; Peter M. Visscher; Nilanjan Chatterjee; Ruth J. F. Loos; Michael Boehnke; Mark I. McCarthy; Erik Ingelsson; Cecilia M. Lindgren; Gonçalo R. Abecasis; Kāri Stefánsson; Timothy M. Frayling; Joel N. Hirschhorn

doi:10.1038/nature09410

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Hana Lango Allen(University of Exeter), Karol Estrada(Erasmus University Rotterdam), Guillaume Lettre(Montreal Heart Institute), Sonja I. Berndt(National Institutes of Health), Michael N. Weedon(University of Exeter), Fernando Rivadeneira(Erasmus University Rotterdam), Cristen J. Willer(University of Michigan), Anne Jackson(University of Michigan), Sailaja Vedantam(Boston Children's Hospital), Soumya Raychaudhuri(Broad Institute), Teresa Ferreira(Centre for Human Genetics), Andrew R. Wood(University of Exeter), Robert J. Weyant(University of Michigan), Ayellet V. Segrè(Broad Institute), Elizabeth K. Speliotes(Broad Institute), Eleanor Wheeler(Wellcome Sanger Institute), Nicole Soranzo(Wellcome Sanger Institute), Ju‐Hyun Park(National Institutes of Health), Jian Yang(QIMR Berghofer Medical Research Institute), Daníel F. Guðbjartsson(deCODE Genetics (Iceland)), Nancy L. Heard‐Costa(Boston University), Joshua C. Randall(Centre for Human Genetics), Lu Qi(Harvard University), Albert V. Smith(Icelandic Heart Association), Reedik Mägi(Centre for Human Genetics), Tomi Pastinen(McGill University and Génome Québec Innovation Centre), Liming Liang(Harvard University), Iris M. Heid, Jian’an Luan(Addenbrooke's Hospital), Guðmar Þorleifsson(deCODE Genetics (Iceland)), Thomas W. Winkler, Michael E. Goddard(The University of Melbourne), Ken Sin Lo(Montreal Heart Institute), Cameron D. Palmer(Boston Children's Hospital), Tsegaselassie Workalemahu(Harvard University), Yurii S. Aulchenko(Netherlands Consortium for Healthy Ageing), Åsa Johansson(Uppsala University), M. Carola Zillikens(Erasmus University Rotterdam), Mary F. Feitosa(Washington University in St. Louis), Tõnu Esko(University of Tartu), Toby Johnson(University of Lausanne), Shamika Ketkar(Washington University in St. Louis), Peter Kraft(Harvard University), Massimo Mangino(King's College London), Inga Prokopenko(Centre for Human Genetics), Devin Absher(HudsonAlpha Institute for Biotechnology), Eva Albrecht(Helmholtz Zentrum München), Florian Ernst(Universität Greifswald), Nicole L. Glazer(University of Washington), Caroline Hayward(Western General Hospital), Jouke‐Jan Hottenga(Vrije Universiteit Amsterdam), Kevin B. Jacobs(Science Applications International Corporation (United States)), Joshua W. Knowles(Stanford University), Zoltán Kutalik(University of Lausanne), Keri L. Monda(University of North Carolina at Chapel Hill), Ozren Polašek(University of Zagreb), Michael Preuß(University of Lübeck), Nigel W. Rayner(Centre for Human Genetics), Neil R. Robertson(Centre for Human Genetics), Valgerður Steinthórsdóttir(deCODE Genetics (Iceland)), Jonathan P. Tyrer(University of Cambridge), Benjamin F. Voight(Broad Institute), Fredrik Wiklund(Karolinska Institutet), Jianfeng Xu(Wake Forest University), Wei Zhao(Addenbrooke's Hospital), Dale R. Nyholt(QIMR Berghofer Medical Research Institute), Niina Pellikka(University of Helsinki), Markus Perola(University of Helsinki), John R. B. Perry(University of Exeter), Ida Surakka(University of Helsinki), Mari‐Liis Tammesoo(University of Tartu), Elizabeth L. Altmaier(Broad Institute), Najaf Amin(Erasmus University Rotterdam), Thor Aspelund(Icelandic Heart Association), Tushar Bhangale(University of Washington), Gabrielle Boucher(Montreal Heart Institute), Daniel I. Chasman(Brigham and Women's Hospital), Constance Chen(Harvard University), Lachlan Coin(Imperial College London), Matthew N. Cooper(The University of Western Australia), Anna Dixon(Royal National Hospital for Rheumatic Diseases), Quince Gibson(University of Maryland, Baltimore), Elin Grundberg(Wellcome Sanger Institute), Ke Hao(Rosetta Stone (United States)), Juhani Junttila(University of Oulu), Lee M. Kaplan(Massachusetts General Hospital), Johannes Kettunen(University of Helsinki), Inke R. König(University of Lübeck), Tony Kwan(McGill University and Génome Québec Innovation Centre), Robert Lawrence(The University of Western Australia), Douglas F. Levinson(Stanford University), Mattias Lorentzon(University of Gothenburg), Barbara McKnight(University of Washington), Andrew P. Morris(Centre for Human Genetics), Martina Müller‐Nurasyid(Helmholtz Zentrum München), Julius S. Ngwa(Boston University), Shaun Purcell(Massachusetts General Hospital), Suzanne Rafelt(University of Leicester), Rany M. Salem(Broad Institute), Erika Salvi(University of Milan), Serena Sanna(Institute of Genetic and Biomedical Research), Jianxin Shi(National Institutes of Health), Ulla Sovio(Imperial College London), John R. Thompson(Glenfield Hospital), Michael C. Turchin(Broad Institute), Liesbeth Vandenput(University of Gothenburg), Dominique J. Verlaan(McGill University and Génome Québec Innovation Centre), Véronique Vitart(Western General Hospital), Charles C. White(Boston University), Andreas Ziegler(University of Lübeck), Peter Almgren(Lund University), Anthony J. Balmforth(University of Leeds), Harry Campbell(University of Edinburgh), Lorena Citterio(Vita-Salute San Raffaele University), Alessandro De Grandi(Eurac Research), Anna F. Dominiczak(British Heart Foundation), Jubao Duan(NorthShore University HealthSystem), Paul Elliott(Imperial College London), Roberto Elosúa(Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública), Johan G. Eriksson(University of Helsinki), Nelson B. Freimer(University of California, Los Angeles), Eco J. C. de Geus(Vrije Universiteit Amsterdam), Nicola Glorioso(University of Sassari), Haiqing Shen(University of Maryland, Baltimore), Anna-Liisa Hartikainen(University of Oulu), Aki S. Havulinna(Finnish Institute for Health and Welfare), Andrew A. Hicks(Eurac Research), Jennie Hui(The University of Western Australia), Wilmar Igl(Uppsala University), Thomas Illig(Helmholtz Zentrum München), Antti Jula(Finnish Institute for Health and Welfare), Eero Kajantie(Finnish Institute for Health and Welfare), Tuomas O. Kilpeläinen(Addenbrooke's Hospital), Markku Koiranen(University of Oulu), Ivana Kolčić(University of Zagreb), Seppo Koskinen(Finnish Institute for Health and Welfare), Péter Kovács, Jaana Laitinen(Finnish Institute of Occupational Health), Jianjun Liu(Genome Institute of Singapore), Marja‐Liisa Lokki(University of Helsinki), Ana Marušić(University of Split), Andrea Maschio(Institute of Genetic and Biomedical Research), Thomas Meitinger(TUM Klinikum), Antonella Mulas(Institute of Genetic and Biomedical Research), Guillaume Paré(McMaster University), Alex Parker(Amgen (United States)), John F. Peden(Centre for Human Genetics), Astrid Petersmann(Universitätsmedizin Greifswald), Irene Pichler(Eurac Research), Kirsi H. Pietiläinen(University of Helsinki), Anneli Pouta(University of Oulu), Martin Ridderstråle(Lund University), Jerome I. Rotter(Cedars-Sinai Medical Center), Jennifer G. Sambrook(University of Cambridge), Alan R. Sanders(NorthShore University HealthSystem), Carsten Oliver Schmidt(Universitätsmedizin Greifswald), Juha Sinisalo(Helsinki University Hospital), Jan Smit(Amsterdam UMC Location Vrije Universiteit Amsterdam), Heather M. Stringham(University of Michigan), G. Bragi Walters(deCODE Genetics (Iceland)), Elisabeth Widén(University of Helsinki), Sarah H. Wild(University of Edinburgh), Gonneke Willemsen(Vrije Universiteit Amsterdam), Laura Zagato(Vita-Salute San Raffaele University), Lina Zgaga(University of Zagreb), Paavo Zitting(Lapland Central Hospital), Helene Alavere(University of Tartu), Martin Farrall(Centre for Human Genetics), Wendy L. McArdle(University of Bristol), Mari Nelis(University of Tartu), Marjolein J. Peters(Netherlands Consortium for Healthy Ageing), Samuli Ripatti(University of Helsinki), Joyce B. J. van Meurs(Netherlands Consortium for Healthy Ageing), Katja K.H. Aben(Netherlands Comprehensive Cancer Organisation), Kristin Ardlie(Broad Institute), J. Beckmann(University of Lausanne), John Beilby(Queen Elizabeth II Medical Centre), Richard N. Bergman(University of Southern California), Sven Bergmann(SIB Swiss Institute of Bioinformatics), Francis S. Collins(National Institutes of Health), Daniele Cusi(University of Milan), Martin den Heijer(Radboud University Nijmegen), Guðný Eiríksdóttir(Icelandic Heart Association), Pablo V. Gejman(NorthShore University HealthSystem), Alistair S. Hall(University of Leeds), Anders Hamsten(Karolinska University Hospital), Heikki V. Huikuri(University of Oulu), Carlos Iribarren(Kaiser Permanente), Mika Kähönen(Tampere University Hospital), Jaakko Kaprio(University of Helsinki), Sekar Kathiresan(Massachusetts General Hospital), Lambertus A. Kiemeney(Netherlands Comprehensive Cancer Organisation), Thomas Köcher, Lenore J. Launer(National Institutes of Health), Terho Lehtimäki(Tampere University Hospital), Olle Melander(Lund University), Tom Mosley(University of Mississippi Medical Center), Arthur W. Musk(Sir Charles Gairdner Hospital), Markku S. Nieminen(Helsinki University Hospital), Christopher J. O’Donnell(National Heart Lung and Blood Institute), Claes Ohlsson(University of Gothenburg), Ben A. Oostra(Erasmus University Rotterdam), Lyle J. Palmer(The University of Western Australia), Olli T. Raitakari(University of Turku), Paul M. Ridker(Brigham and Women's Hospital), John D. Rioux(Université de Montréal), Aila Rissanen(Helsinki University Hospital), Carlo Rivolta(University of Lausanne), Heribert Schunkert(University of Lübeck), Alan R. Shuldiner(University of Maryland, Baltimore), David S. Siscovick(University of Washington), Michael Stümvoll(Leipzig University), Anke Tönjes(Leipzig University), Jaakko Tuomilehto(Finnish Institute for Health and Welfare), Gert-Jan van Ommen(Leiden University Medical Center), Jorma Viikari(University of Turku), Andrew C. Heath(Washington University in St. Louis), Nicholas G. Martin(QIMR Berghofer Medical Research Institute), Grant W. Montgomery(QIMR Berghofer Medical Research Institute), Michael A. Province(Washington University in St. Louis), Manfred Kayser(Erasmus University Rotterdam), Alice M. Arnold(University of Washington), Larry D. Atwood(Boston University), Eric Boerwinkle(The University of Texas Health Science Center at Houston), Stephen J. Chanock(National Institutes of Health), Panos Deloukas(Wellcome Sanger Institute), Christian Gieger(Helmholtz Zentrum München), Henrik Grönberg(Karolinska Institutet), Per Hall(Karolinska Institutet), Andrew T. Hattersley(University of Exeter), Christian Hengstenberg(University Hospital Regensburg), Wolfgang Hoffman(Universitätsmedizin Greifswald), G.M. Lathrop(Centre National de Recherche en Génomique Humaine), Veikko Salomaa(Finnish Institute for Health and Welfare), Stefan Schreiber(Christian-Albrechts-Universität zu Kiel), Manuela Uda(Institute of Genetic and Biomedical Research), Dawn Waterworth(GlaxoSmithKline (United States)), Alan F. Wright(Western General Hospital), Themistocles L. Assimes(Stanford University), Inês Barroso(Wellcome Sanger Institute), Albert Hofman(Netherlands Consortium for Healthy Ageing), Karen L. Mohlke(University of North Carolina at Chapel Hill), Dorret I. Boomsma(Vrije Universiteit Amsterdam), Mark J. Caulfield(Queen Mary University of London), L. Adrienne Cupples(Boston University), Jeanette Erdmann(University of Lübeck), Caroline S. Fox(National Heart Lung and Blood Institute), Vilmundur Guðnason(University of Iceland), Ulf Gyllensten(Uppsala University), Tamara B. Harris(National Institutes of Health), Richard B. Hayes(Columbia University Irving Medical Center), Marjo‐Riitta Järvelin(Imperial College London), Vincent Mooser(GlaxoSmithKline (United States)), Patricia B. Munroe(Queen Mary University of London), Willem H. Ouwehand(University of Cambridge), Brenda W.J.H. Penninx(Amsterdam UMC Location Vrije Universiteit Amsterdam), Peter P. Pramstaller(Eurac Research), Thomas Quertermous(Stanford University), Igor Rudan(University of Split), Nilesh J. Samani(University of Leicester), Timothy D. Spector(King's College London), Henry Völzke(Universitätsmedizin Greifswald), Hugh Watkins(John Radcliffe Hospital), James F. Wilson(University of Edinburgh), Leif Groop(Lund University), Talin Haritunians(Cedars-Sinai Medical Center), Frank B. Hu(Harvard University), Robert C. Kaplan(Albert Einstein College of Medicine), Andres Metspalu(University of Tartu), Kari E. North(University of North Carolina at Chapel Hill), David Schlessinger(National Institute on Aging), Nicholas J. Wareham(Addenbrooke's Hospital), David J. Hunter(Harvard University), Jeffrey R. O’Connell(University of Maryland, Baltimore), David P. Strachan(St George's, University of London), H.‐Erich Wichmann(Ludwig-Maximilians-Universität München), Ingrid B. Borecki(Washington University in St. Louis), Cornelia M. van Duijn(Netherlands Consortium for Healthy Ageing), Eric E. Schadt(Pacific Biosciences (United States)), Unnur Þorsteinsdóttir(University of Iceland), Leena Peltonen(Broad Institute), André G. Uitterlinden(Netherlands Consortium for Healthy Ageing), Peter M. Visscher(QIMR Berghofer Medical Research Institute), Nilanjan Chatterjee(National Institutes of Health), Ruth J. F. Loos(Addenbrooke's Hospital), Michael Boehnke(University of Michigan), Mark I. McCarthy(University of Oxford), Erik Ingelsson(Karolinska Institutet), Cecilia M. Lindgren(University of Oxford), Gonçalo R. Abecasis(University of Michigan), Kāri Stefánsson(University of Iceland), Timothy M. Frayling(University of Exeter), Joel N. Hirschhorn(Harvard University)

Nature

September 29, 2010

10.1038/nature09410

Cited by 2,057Open Access

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