Galaxy: A platform for interactive large-scale genome analysis

Belinda Giardine(Pennsylvania State University), Cathy Riemer(Pennsylvania State University), Ross C. Hardison(Pennsylvania State University), Richard Burhans(Pennsylvania State University), Laura Elnitski(National Human Genome Research Institute), Prachi Shah(Pennsylvania State University), Yi Zhang(Pennsylvania State University), Daniel Blankenberg(Pennsylvania State University), István Albert(Pennsylvania State University), James Taylor(Pennsylvania State University), Webb Miller(Pennsylvania State University), W. James Kent(University of California, Santa Cruz), Anton Nekrutenko(Pennsylvania State University)
Genome Research
September 16, 2005
Cited by 2,068Open Access
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Abstract

Accessing and analyzing the exponentially expanding genomic sequence and functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines the power of existing genome annotation databases with a simple Web portal to enable users to search remote resources, combine data from independent queries, and visualize the results. The heart of Galaxy is a flexible history system that stores the queries from each user; performs operations such as intersections, unions, and subtractions; and links to other computational tools. Galaxy can be accessed at http://g2.bx.psu.edu.


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