Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

Kenichiro Doi(Pennsylvania State University), Hong‐Gang Wang(Pennsylvania State University), Wanda Manieri(Moffitt Cancer Center), E. Schönbrunn(University of South Florida), Andy Awwad(Penn State Milton S. Hershey Medical Center), Rongshi Li(Moffitt Cancer Center), Shantu Amin(Pennsylvania State University), Thomas P. Loughran(University of Virginia Cancer Center), Gary W. Daughdrill(Target (United States)), Krishne Gowda(Pennsylvania State University), Yan Liu(Chongqing Medical University), Xin Liu(Beijing Radiation Center), Hongwei Wu(University of South Florida), Saı̈d M. Sebti(Moffitt Cancer Center), Shen‐Shu Sung(Pennsylvania State University), Alden Dewey(Penn State Milton S. Hershey Medical Center), Chunwei Cheng(Sichuan University), Yong Qin(National Medical Products Administration)
Journal of Biological Chemistry
February 7, 2012
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