Three‐Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells
Shutao Wang(California NanoSystems Institute), Hao Wang(California NanoSystems Institute), Jing Jiao(California NanoSystems Institute), Kuan‐Ju Chen(California NanoSystems Institute), Gwen E. Owens(California NanoSystems Institute), Ken‐ichiro Kamei(California NanoSystems Institute), Jing Sun(California NanoSystems Institute), David J. Sherman(California NanoSystems Institute), Christian Behrenbruch(California NanoSystems Institute), Hong Wu(California NanoSystems Institute), Hsian‐Rong Tseng(California NanoSystems Institute)
Cited by 507Open Access
Abstract
A grabby substrate: A 3D nanostructured substrate, namely, a silicon-nanopillar (SiNP) array coated with epithelial-cell adhesion-molecule antibody (anti-EpCAM), shows enhanced local topographic interactions between nanoscale cell-surface components and the substrates surface, resulting in enhanced cell-capture efficiency when employed to isolate viable cancer cells from whole-blood samples (see schematic and SEM image of a captured cancer cell).
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