Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent

Timothy R. Rebbeck(University of Pennsylvania), Susan S. Devesa(National Cancer Institute), Bao‐Li Chang(University of Pennsylvania), Clareann H. Bunker(University of Pittsburgh), Iona Cheng(Cancer Prevention Institute of California), Kathleen A. Cooney(University of Michigan), Rosalind A. Eeles(Royal Marsden NHS Foundation Trust), P. Fernandez(Stellenbosch University), Veda N. Giri(Fox Chase Cancer Center), Sérigne Maguèye Gueye(Cheikh Anta Diop University), Christopher A. Haiman(University of Southern California), Brian E. Henderson(University of Southern California), Chris Heyns(Stellenbosch University), Jennifer J. Hu(University of Miami), Sue A. Ingles(University of Southern California), William B. Isaacs(Johns Hopkins University), Mohamed Jalloh(Cheikh Anta Diop University), Esther M. John(Cancer Prevention Institute of California), Adam S. Kibel(Brigham and Women's Hospital), LaCreis R. Kidd(University of Louisville), Penelope Layne(University of Guyana), Robin J. Leach(The University of Texas at San Antonio Health Science Center), Christine Neslund‐Dudas(Henry Ford Hospital), Michael Okobia(University of Pittsburgh), Elaine A. Ostrander(National Human Genome Research Institute), Jong Y. Park(Moffitt Cancer Center), Alan L. Patrick(University of Trinidad and Tobago), Catherine M. Phelan(Moffitt Cancer Center), Camille Ragin(Fox Chase Cancer Center), Robin Roberts(University of the West Indies), Benjamin A. Rybicki(Henry Ford Hospital), Janet L. Stanford(Fred Hutch Cancer Center), Sara S. Strom(The University of Texas MD Anderson Cancer Center), Ian M. Thompson(The University of Texas at San Antonio Health Science Center), John S. Witte(University of California, San Francisco), Jianfeng Xu(Wake Forest University), Edward D. Yeboah(University of Ghana), Ann W. Hsing(National Cancer Institute), Charnita Zeigler‐Johnson(University of Pennsylvania)
Prostate Cancer
January 1, 2013
10.1155/2013/560857
Cited by 270Open Access
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Abstract

Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world.

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