Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture

Marcos de Lima(The University of Texas MD Anderson Cancer Center), Ian McNiece(The University of Texas MD Anderson Cancer Center), Simon N. Robinson(The University of Texas MD Anderson Cancer Center), Mark F. Munsell(The University of Texas MD Anderson Cancer Center), Mary Eapen(Medical College of Wisconsin), Mary M. Horowitz(Medical College of Wisconsin), Amin M. Alousi(The University of Texas MD Anderson Cancer Center), Rima M. Saliba(The University of Texas MD Anderson Cancer Center), John D. McMannis(Mesoblast (United States)), Indreshpal Kaur(The University of Texas MD Anderson Cancer Center), Partow Kebriaei(The University of Texas MD Anderson Cancer Center), Simrit Parmar(The University of Texas MD Anderson Cancer Center), Uday Popat(The University of Texas MD Anderson Cancer Center), Chitra Hosing(The University of Texas MD Anderson Cancer Center), Richard E. Champlin(The University of Texas MD Anderson Cancer Center), Catherine M. Bollard(Baylor College of Medicine), Jeffrey J. Molldrem(The University of Texas MD Anderson Cancer Center), Roy B. Jones(The University of Texas MD Anderson Cancer Center), Yago Nieto(The University of Texas MD Anderson Cancer Center), Börje S. Andersson(The University of Texas MD Anderson Cancer Center), Nina Shah(The University of Texas MD Anderson Cancer Center), Betül Oran(The University of Texas MD Anderson Cancer Center), Laurence J.N. Cooper(The University of Texas MD Anderson Cancer Center), Laura L. Worth(The University of Texas MD Anderson Cancer Center), Muzaffar H. Qazilbash(The University of Texas MD Anderson Cancer Center), Martin Körbling(The University of Texas MD Anderson Cancer Center), Gabriela Rondón(The University of Texas MD Anderson Cancer Center), Stefan O. Ciurea(The University of Texas MD Anderson Cancer Center), Doyle Bosque(The University of Texas MD Anderson Cancer Center), I. Maewal(The University of Texas MD Anderson Cancer Center), Paul J. Simmons(Mesoblast (United States)), Elizabeth J. Shpall(The University of Texas MD Anderson Cancer Center)
New England Journal of Medicine
December 12, 2012
10.1056/nejmoa1207285
Cited by 475Open Access
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Abstract

Poor engraftment due to low cell doses restricts the usefulness of umbilical-cord-blood transplantation. We hypothesized that engraftment would be improved by transplanting cord blood that was expanded ex vivo with mesenchymal stromal cells.

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