The mammalian gene function resource: the international knockout mouse consortium
Allan Bradley(Wellcome Sanger Institute), Konstantinos Anastassiadis(Technische Universität Dresden), A. Ayadi(Institut Clinique de la Souris), James F. Battey(National Institute on Deafness and Other Communication Disorders), Cindy Bell(Genome Canada), Marie‐Christine Birling(Institut Clinique de la Souris), Joanna Bottomley(Wellcome Sanger Institute), Steve D. M. Brown(Mary Lyon Centre at MRC Harwell), Antje Bürger(Helmholtz Zentrum München), Carol J. Bult(Jackson Laboratory), Wendy Bushell(Wellcome Sanger Institute), Francis S. Collins(National Institutes of Health), Christian Desaintes(European Commission), Brendan Doe(Institute of Cell Biology and Neurobiology), Aris N. Economides(Regeneron (United States)), Janan T. Eppig(Jackson Laboratory), Richard H. Finnell(The University of Texas at Austin), Colin Fletcher(National Institutes of Health), Martin Fray(Mary Lyon Centre at MRC Harwell), David Frendewey(Regeneron (United States)), Roland H. Friedel(Helmholtz Zentrum München), Frank Grosveld(Erasmus MC), Jens Hansen(Helmholtz Zentrum München), Yann Hérault(Institut Clinique de la Souris), Geoffrey G. Hicks(University of Manitoba), Andreas Hörlein(Helmholtz Zentrum München), Richard Houghton(Wellcome Sanger Institute), Martin Hrabě de Angelis(Helmholtz Zentrum München), Danny Huylebroeck(KU Leuven), Vivek Iyer(Wellcome Sanger Institute), Pieter J. de Jong(Oaklands Hospital), James A. Kadin(Jackson Laboratory), Cornelia Kaloff(Helmholtz Zentrum München), Karen L. Kennedy(Wellcome Sanger Institute), Manousos Koutsourakis(Wellcome Sanger Institute), K. C. Kent Lloyd(University of California, Davis), Susan Marschall(Helmholtz Zentrum München), Jeremy Mason(Jackson Laboratory), Colin McKerlie(SickKids Foundation), Michael P. McLeod(Texas A&M University), Harald von Melchner(Goethe University Frankfurt), Mark W. Moore(National Institutes of Health), Alejandro O. Mujica(Regeneron (United States)), András Nagy(Mount Sinai Hospital), Mikhail Nefedov(Oaklands Hospital), Lauryl M. J. Nutter(SickKids Foundation), Guillaume Pavlovic(Institut Clinique de la Souris), Jane L. Peterson(National Institutes of Health), Jonathan D. Pollock(National Institute on Drug Abuse), Ramiro Ramírez‐Solis(Wellcome Sanger Institute), Derrick E. Rancourt(University of Calgary), Marcello Raspa(Institute of Cell Biology and Neurobiology), Jacques Remacle(European Commission), Martin Ringwald(Jackson Laboratory), Barry P. Rosen(Wellcome Sanger Institute), Nadia Rosenthal(European Molecular Biology Laboratory), Janet Rossant(SickKids Foundation), Patricia Ruíz(German Centre for Cardiovascular Research), Edward J. Ryder(Wellcome Sanger Institute), Joel Schick(Helmholtz Zentrum München), Frank Schnütgen(Goethe University Frankfurt), Paul N. Schofield(University of Cambridge), Claudia Seisenberger(Helmholtz Zentrum München), Mohammed Selloum(Institut Clinique de la Souris), Elizabeth M. Simpson(University of British Columbia), William C. Skarnes(Wellcome Sanger Institute), Damian Smedley(European Bioinformatics Institute), William L. Stanford(Ottawa Hospital), A. Francis Stewart(Technische Universität Dresden), Kevin Stone(Jackson Laboratory), Kate Swan(Genome Canada), Hamsa D. Tadepally(Jackson Laboratory), Lydia Teboul(Mary Lyon Centre at MRC Harwell), Glauco P. Tocchini‐Valentini(Institute of Cell Biology and Neurobiology), David M. Valenzuela(Regeneron (United States)), Anthony P. West(Wellcome Sanger Institute), Ken‐ichi Yamamura(Kumamoto University), Yuko Yoshinaga(Oaklands Hospital), Wolfgang Wurst(German Center for Neurodegenerative Diseases)
Cited by 326Open Access
Abstract
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
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