Enzymatic Resolution of Alcohols Coupled with Ruthenium‐Catalyzed Racemization of the Substrate Alcohol

Abstract

A specifically designed acyl donor, an efficient enzyme, and a stable and reliable ruthenium catalyst are fundamental for the resolution of the racemic alcohols described here (see scheme on the right). For R1  Ph and R2  Me, 100% conversion into the corresponding acetate was achieved with greater than 99.5% ee.