A Genomic Regulatory Network for Development
Eric H. Davidson(California Institute of Technology), Jonathan P. Rast(California Institute of Technology), Paola Oliveri(California Institute of Technology), Andrew Ransick(California Institute of Technology), Cristina Calestani(California Institute of Technology), Chiou‐Hwa Yuh(California Institute of Technology), Takuya Minokawa(California Institute of Technology), Gabriele Amore(California Institute of Technology), Veronica F. Hinman(California Institute of Technology), César Arenas‐Mena(California Institute of Technology), Ochan Otim(California Institute of Technology), C. Titus Brown(California Institute of Technology), Carolina B. Livi(California Institute of Technology), Pei Yun Lee(California Institute of Technology), Roger Revilla‐i‐Domingo(California Institute of Technology), Alistair G. Rust(University of Hertfordshire), Zheng jun Pan(University of Hertfordshire), Maria J. Schilstra(University of Hertfordshire), Peter Clarke(University of Hertfordshire), Maria Ina Arnone(Stazione Zoologica Anton Dohrn), Lee Rowen(Institute for Systems Biology), R. Andrew Cameron(California Institute of Technology), David R. McClay(Duke University), Leroy Hood(Institute for Systems Biology), Hamid Bolouri(University of Hertfordshire)
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Abstract
Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.
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