Production of the Antifungal Isochromanone Ajudazols A and B in <i>Chondromyces crocatus</i> Cm c5: Biosynthetic Machinery and Cytochrome P450 Modifications

Abstract

Unusual biochemistry: The pathway to the antifungal ajudazols (ajudazol A is shown) has been deduced by cloning and sequencing of the gene cluster in the myxobacterium Chondromyces crocatus, coupled with insertional mutagenesis. Ajudazol biosynthesis incorporates several unusual features, including the first P450-catalyzed dehydrogenation identified in bacterial metabolism. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705569_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.