Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Richard A. Miller(University of Michigan), David E. Harrison(ASTER), Clinton M. Astle(College of the Atlantic), Joseph A. Baur(Sanofi (France)), Angela R. Boyd(The University of Texas Health Science Center at San Antonio), Rafael de Cabo(National Institute on Aging), Elizabeth Fernández(The University of Texas Health Science Center at San Antonio), Kevin Flurkey(Jackson Laboratory), Martin A. Javors(The University of Texas Health Science Center at San Antonio), James F. Nelson(The University of Texas Health Science Center at San Antonio), Carlos J. Orihuela(The University of Texas Health Science Center at San Antonio), Scott D. Pletcher(University of Michigan), Z. Dave Sharp(The University of Texas Health Science Center at San Antonio), David Sinclair(Harvard University), Joseph W. Starnes(University of North Carolina at Greensboro), John E. Wilkinson(Michigan Medicine), Nancy L. Nadon(National Institute on Aging), Randy Strong(The University of Texas Health Science Center at San Antonio)
The Journals of Gerontology Series A
October 25, 2010
10.1093/gerona/glq178
Cited by 910Open Access
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Abstract

A GENTSthatcanextendthe lifespanofmiceareof interestfortworeasons:theycanprovidenewmodels of delayed aging to teach us more about what controls agingrateandhowagingleadstodisease;andinaddition, they serve as a first step toward eventual development of pharmaceuticals to slow aging and retard diseases in humans. The National Institute on Aging Intervention Testingprogram(ITP)haspreviouslyreportedsignificant increases in life span caused by aspirin and nordihydroguaiareticacid inmalemice(1)andbyrapamycinin bothmaleandfemalemice(2).ThedesignoftheITP(3) emphasizestheuseofgeneticallyheterogeneousmiceto mitigate against idiosyncrasies that can complicate inter-pretationofdatafromasingleinbredorF1hybridstock andincludesparallelreplicationofprotocolsatthreesites, the University of Texas (UT), University of Michigan (UM), and The Jackson Laboratory (TJL), with standard operatingprotocolsthatattempttoreproducekeyelements of the environmental conditions at each site. Sufficient numbers of mice are used in each yearly cohort to give morethan80%powertodetectanincreaseordecreaseof 10%inmeanlifespan,withrespecttocontrolsofthesame sex,evenifonlytwoofthethreesitescancontributedata tothepooledanalysis.

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