Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Zhi-Hua Chen(Harvard University), Hong Pyo Kim(Harvard University), Frank C. Sciurba(University of Pittsburgh), Seon‐Jin Lee(Brigham and Women's Hospital), Carol Feghali‐Bostwick(University of Pittsburgh), Donna B. Stolz(University of Pittsburgh), Rajiv Dhir(University of Pittsburgh), Rodney J. Landreneau(University of Pittsburgh), Mathew J. Schuchert(University of Pittsburgh), Samuel A. Yousem(University of Pittsburgh), Kiichi Nakahira(University of Pittsburgh), Joseph M. Pilewski(University of Pittsburgh), Janet Lee(University of Pittsburgh), Yingze Zhang(University of Pittsburgh), Stefan W. Ryter(Brigham and Women's Hospital), Augustine M.K. Choi(Brigham and Women's Hospital)
Cited by 463Open Access
Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear.
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