Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry
Dirk T. S. Rijkers(Utrecht University), G. Wilma van Esse(Utrecht University), Remco Merkx(Utrecht University), Arwin J. Brouwer(Utrecht University), Hans J. F. Jacobs(Utrecht University), Roland J. Pieters(Utrecht University), Rob M. J. Liskamp(Utrecht University)
Cited by 130
Abstract
Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.
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