Localization of a Breast Cancer Susceptibility Gene, <i>BRCA2</i> , to Chromosome 13q12-13
Richard Wooster(Institute of Cancer Research), Susan L. Neuhausen(University of Utah), Jonathan Mangion(Institute of Cancer Research), Yvette Quirk(Institute of Cancer Research), Deborah Ford(Institute of Cancer Research), Nadine Collins(Institute of Cancer Research), Kim Nguyễn(University of Utah), Sheila Seal(Institute of Cancer Research), Thao Tran(University of Utah), D. Averill(Institute of Cancer Research), Patty Fields(University of Utah), Gill Marshall(Institute of Cancer Research), Steven A. Narod(Centre For Human Genetics), Gilbert Lenoir(Centre international de recherche sur le cancer), Henry T. Lynch(Creighton University), Jean Feunteun(Institut Gustave Roussy), Peter Devilee(Leiden University), Cees J. Cornelisse(Leiden University), Fred H. Menko(University of Amsterdam), Peter A. Daly(Trinity College Dublin), W. Ormiston(Trinity College Dublin), Ross McManus(Trinity College Dublin), Carole Pye(Cancer Research UK), Cathryn M. Lewis(University of Utah), Lisa Cannon‐Albright(University of Utah), Julian Peto(Institute of Cancer Research), Bruce A.J. Ponder(Cancer Research UK), Mark H. Skolnick(University of Utah), Douglas F. Easton(Institute of Cancer Research), David E. Goldgar(University of Utah), Michael R. Stratton(Institute of Cancer Research)
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Abstract
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
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