Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2
Arya Biragyn(National Cancer Institute), Pier Adelchi Ruffini(National Cancer Institute), Cynthia A. Leifer(National Cancer Institute), Elena Klyushnenkova, Alexander Shakhov, Oleg Chertov(Science Applications International Corporation (United States)), Aiko K. Shirakawa(National Institutes of Health), Joshua Μ. Farber(National Institutes of Health), David M. Segal(National Cancer Institute), Joost J. Oppenheim(Frederick National Laboratory for Cancer Research), Larry W. Kwak(National Cancer Institute)
Cited by 889
Abstract
beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.
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