Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

Hou‐Feng Zheng; Vincenzo Forgetta; Yi‐Hsiang Hsu; Karol Estrada; Alberto Roselló‐Díez; Paul Leo; Chitra Lekha Dahia; Kyung Hyun Park‐Min; Jonathan H. Tobias; Charles Kooperberg; Aaron Kleinman; Unnur Styrkársdóttir; Ching‐Ti Liu; Charlotta Uggla; Daniel S. Evans; Carrie M. Nielson; Klaudia Walter; U. Pettersson; Shane McCarthy; Joel Eriksson; Tony Kwan; Mila Jhamai; Katerina Trajanoska; Yasin Memari; Josine L. Min; Jie Huang; Petr Danecek; Beth Wilmot; Rui Li; Wen‐Chi Chou; Lauren E. Mokry; Alireza Moayyeri; Melina Claussnitzer; Chia‐Ho Cheng; Warren Cheung; Carolina Medina‐Gómez; Bing Ge; Shu‐Huang Chen; Kwangbom Choi; Ling Oei; James A. Fraser; Robert Kraaij; Matthew Hibbs; Celia L. Gregson; Denis Paquette; Albert Hofman; Carl Wibom; Gregory J. Tranah; Mhairi Marshall; Brooke Gardiner; Katie Cremin; Paul L. Auer; Li Hsu; Sue Ring; Joyce Y. Tung; Gudmar Thorleifsson; Anke W. Enneman; Natasja M. van Schoor; C.P.G.M. de Groot; Nathalie van der Velde; Beatrice Melin; John P. Kemp; Claus Christiansen; Adrian Sayers; Yanhua Zhou; Sophie Caldérari; Jeroen van Rooij; Chris Carlson; Ulrike Peters; Soizik Berlivet; Josée Dostie; André G. Uitterlinden; Stephen R. Williams; Charles R. Farber; Daniel Grinberg; Andrea Z. LaCroix; Jeff Haessler; Daniel I. Chasman; Franco Giulianini; Lynda M. Rose; Paul M. Ridker; John A. Eisman; Tuan V. Nguyen; Xavier Nogués; Natalia García‐Giralt; Lenore L. Launer; Vilmunder Gudnason; Dan Mellström; Liesbeth Vandenput; Najaf Amin; Cornelia M. van Duijn; Magnus K. Karlsson; Östen Ljunggren; Olle Svensson; Göran Hallmans; François Rousseau; Sylvie Giroux; Johanne Bussière; Pascal Arp; Fjorda Koromani; Richard L. Prince; Joshua R. Lewis; Bente Langdahl; Anne Pernille Hermann; Jens‐Erik Beck Jensen; Stephen Kaptoge; Kay‐Tee Khaw; J. Reeve; Melissa M. Formosa; Angela Xuereb‐Anastasi; Kristina Åkesson; Fiona E. McGuigan; Gaurav Garg; José M. Olmos; Marı́a T. Zarrabeitia; José A. Riancho; Stuart H. Ralston; Nerea Alonso; Xi Jiang; David Goltzman; Tomi Pastinen; Elin Grundberg; Dominique Gauguier; Eric Orwoll; David Karasik; George Davey‐Smith; Albert V. Smith; Kristín Siggeirsdóttir; Tamara B. Harris; M. Carola Zillikens; Joyce B. J. van Meurs; Unnur A. Thorsteinsdottir; Matthew T. Maurano; Nicholas J. Timpson; Nicole Soranzo; Richard Durbin; Scott G. Wilson; Evangelia Ntzani; Matthew A. Brown; Kari Stefansson; David A. Hinds; T. D. Spector; L. Adrienne Cupples; Claes Ohlsson; Celia M.T. Greenwood; Rebecca D. Jackson; David W. Rowe; Cynthia A. Loomis; David M. Evans; Cheryl L. Ackert‐Bicknell; Alexandra L. Joyner; Emma L. Duncan; Douglas P. Kiel; Fernando Rivadeneira; J. Brent Richards

doi:10.1038/nature14878

Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

Hou‐Feng Zheng(Jewish General Hospital), Vincenzo Forgetta(Jewish General Hospital), Yi‐Hsiang Hsu(Broad Institute), Karol Estrada(Broad Institute), Alberto Roselló‐Díez(Kettering University), Paul Leo(Translational Research Institute), Chitra Lekha Dahia(Hospital for Special Surgery), Kyung Hyun Park‐Min(Hospital for Special Surgery), Jonathan H. Tobias(University of Bristol), Charles Kooperberg(Fred Hutch Cancer Center), Aaron Kleinman(23andMe (United States)), Unnur Styrkársdóttir(deCODE Genetics (Iceland)), Ching‐Ti Liu(Boston University), Charlotta Uggla(University of Gothenburg), Daniel S. Evans(California Pacific Medical Center), Carrie M. Nielson(Oregon Health & Science University), Klaudia Walter(Wellcome Sanger Institute), U. Pettersson(Umeå University), Shane McCarthy(Wellcome Sanger Institute), Joel Eriksson(University of Gothenburg), Tony Kwan(McGill University and Génome Québec Innovation Centre), Mila Jhamai(Erasmus MC), Katerina Trajanoska(Erasmus MC), Yasin Memari(Wellcome Sanger Institute), Josine L. Min(University of Bristol), Jie Huang(Wellcome Sanger Institute), Petr Danecek(Wellcome Sanger Institute), Beth Wilmot(Oregon Health & Science University), Rui Li(Jewish General Hospital), Wen‐Chi Chou(Harvard University), Lauren E. Mokry(Jewish General Hospital), Alireza Moayyeri(King's College London), Melina Claussnitzer(Broad Institute), Chia‐Ho Cheng(Hebrew SeniorLife), Warren Cheung(McGill University and Génome Québec Innovation Centre), Carolina Medina‐Gómez(Erasmus MC), Bing Ge(McGill University and Génome Québec Innovation Centre), Shu‐Huang Chen(McGill University and Génome Québec Innovation Centre), Kwangbom Choi(University of Rochester), Ling Oei(Erasmus MC), James A. Fraser(McGill University), Robert Kraaij(Erasmus MC), Matthew Hibbs(University of Rochester), Celia L. Gregson(University of Bristol), Denis Paquette(McGill University), Albert Hofman(Erasmus MC), Carl Wibom(Umeå University), Gregory J. Tranah(Oregon Health & Science University), Mhairi Marshall(Translational Research Institute), Brooke Gardiner(Translational Research Institute), Katie Cremin(Translational Research Institute), Paul L. Auer(University of Wisconsin–Milwaukee), Li Hsu(Fred Hutch Cancer Center), Sue Ring(University of Bristol), Joyce Y. Tung(23andMe (United States)), Gudmar Thorleifsson(deCODE Genetics (Iceland)), Anke W. Enneman(Erasmus MC), Natasja M. van Schoor(Amsterdam Public Health), C.P.G.M. de Groot(Wageningen University & Research), Nathalie van der Velde(Erasmus MC), Beatrice Melin(Umeå University), John P. Kemp(Princess Alexandra Hospital), Claus Christiansen(Nordic Bioscience (Denmark)), Adrian Sayers(University of Bristol), Yanhua Zhou(Boston University), Sophie Caldérari(Inserm), Jeroen van Rooij(Erasmus MC), Chris Carlson(Fred Hutch Cancer Center), Ulrike Peters(Fred Hutch Cancer Center), Soizik Berlivet(McGill University), Josée Dostie(McGill University), André G. Uitterlinden(Erasmus MC), Stephen R. Williams(University of Virginia), Charles R. Farber(University of Virginia), Daniel Grinberg(Centre for Biomedical Network Research on Rare Diseases), Andrea Z. LaCroix(UC San Diego Health System), Jeff Haessler(Fred Hutch Cancer Center), Daniel I. Chasman(Brigham and Women's Hospital), Franco Giulianini(Brigham and Women's Hospital), Lynda M. Rose(Brigham and Women's Hospital), Paul M. Ridker(Brigham and Women's Hospital), John A. Eisman(Garvan Institute of Medical Research), Tuan V. Nguyen(Garvan Institute of Medical Research), Xavier Nogués(Universitat Autònoma de Barcelona), Natalia García‐Giralt(Institute on Aging), Lenore L. Launer(National Institute on Aging), Vilmunder Gudnason(National Institutes of Health), Dan Mellström(Icelandic Heart Association), Liesbeth Vandenput(University of Gothenburg), Najaf Amin(University of Gothenburg), Cornelia M. van Duijn(Erasmus MC), Magnus K. Karlsson(Erasmus MC), Östen Ljunggren(Uppsala University), Olle Svensson(Uppsala University), Göran Hallmans(Umeå University), François Rousseau(The Quebec Population Health Research Network), Sylvie Giroux(The Quebec Population Health Research Network), Johanne Bussière(The Quebec Population Health Research Network), Pascal Arp(Erasmus MC), Fjorda Koromani(Erasmus MC), Richard L. Prince(The University of Western Australia), Joshua R. Lewis(The University of Western Australia), Bente Langdahl(Sir Charles Gairdner Hospital), Anne Pernille Hermann(Odense University Hospital), Jens‐Erik Beck Jensen(Odense University Hospital), Stephen Kaptoge(Hvidovre Hospital), Kay‐Tee Khaw(University of Cambridge), J. Reeve(University of Cambridge), Melissa M. Formosa(University of Malta), Angela Xuereb‐Anastasi(University of Malta), Kristina Åkesson(Lund University), Fiona E. McGuigan(Lund University), Gaurav Garg(Lund University), José M. Olmos(Universidad de Cantabria), Marı́a T. Zarrabeitia(Universidad de Cantabria), José A. Riancho(Universidad de Cantabria), Stuart H. Ralston(Universidad de Cantabria), Nerea Alonso(Western General Hospital), Xi Jiang(Western General Hospital), David Goltzman(McGill University), Tomi Pastinen(McGill University and Génome Québec Innovation Centre), Elin Grundberg(McGill University and Génome Québec Innovation Centre), Dominique Gauguier(Inserm), Eric Orwoll(Inserm), David Karasik(Bar-Ilan University), George Davey‐Smith(Bar-Ilan University), Albert V. Smith(University of Iceland), Kristín Siggeirsdóttir(Icelandic Heart Association), Tamara B. Harris(National Institute on Aging), M. Carola Zillikens(National Institutes of Health), Joyce B. J. van Meurs(Erasmus MC), Unnur A. Thorsteinsdottir(deCODE Genetics (Iceland)), Matthew T. Maurano(University of Iceland), Nicholas J. Timpson(University of Washington), Nicole Soranzo(Wellcome Sanger Institute), Richard Durbin(Wellcome Sanger Institute), Scott G. Wilson(The University of Western Australia), Evangelia Ntzani(Rhode Island Department of Health), Matthew A. Brown(University of Ioannina), Kari Stefansson(Translational Research Institute), David A. Hinds(University of Iceland), T. D. Spector(King's College London), L. Adrienne Cupples(Boston University), Claes Ohlsson(Boston University), Celia M.T. Greenwood(McGill University Health Centre), Rebecca D. Jackson(McGill University), David W. Rowe(The Ohio State University), Cynthia A. Loomis(New York University), David M. Evans(California Pacific Medical Center), Cheryl L. Ackert‐Bicknell(University of Bristol), Alexandra L. Joyner(Kettering University), Emma L. Duncan(Royal Brisbane and Women's Hospital), Douglas P. Kiel(Broad Institute), Fernando Rivadeneira(Beth Israel Deaconess Medical Center), J. Brent Richards(King's College London)

Nature

September 14, 2015

10.1038/nature14878

Cited by 626Open Access

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